מחקרים בתחום הקנאביס ותוצאותיהם

מערכת רפואי

מחקרים בתחום הקנאביס ותוצאותיהם

הרבה לפני שענף הקנאביס גלגל מיליונים והפך למסלול קריירה לגיטימי לכל גנרל ומפכ"ל בדימוס או רשא ממשלה לשעבר, גילה פרופ' רפאל משולם את הקנבינואידים, אותם חומרים פעילים בצמח הפופולרי. ב-1964 פרופסור משולם היה החוקר הראשון בעולם שבודד את החומרים האלה. הגילוי שלו הוביל למחקרים נוספים שניסו להבין כיצד המולקולות שבודדו פועלות על גוף האדם. התחום המחקרי בנושא קנאביס נמצא בעלייה מתמדת, בעיקר בזכות התהליכים הכלכליים הנוגעים לגדילה המהירה של התעשיה בשנת 2017. בכל חודש מתפרסמים מספר רב של מחקרים שעוסקים בנושא משלל זוויות שונות, מחקרים אלו מנסים להוכיח את ההשארות הרבות המופצות באופן קבוע במדיות החברתיות השונות.

בשנת 2018 פורסמו מעל 1900 מחקרים מדעיים שקיבלו הכרה מהקהילה המדעית בתחום הקנאביס, ומתחילת שנת 2019 ועד כתיבת הכתבה בסוף אוגוסט, פורסמו מעל ל- 2500 מחקרים מדעיים שקיבלו הכרה מדעית בתחום הקנאביס הרפואי וסגולותיו השונות.

איגדנו עבורכם את המחקרים החשובים ביותר בתחום הקנאביס של השנים האחרונות, והשפעותיו על התוויות רפואיות שונות.

מוזמנים/ות להצטרף לקבוצת הפייסבוק שלנו

Show	Anxiety	Cannabidiol in Anxiety and Sleep: A Large Case Series.	Cannabidiol	CBD may be helpful in anxiety disorders according to a case series
Show		Acute Pharmacokinetic Profile of Smoked and Vaporized Cannabis in Human Blood and Oral Fluid.	Cannabis	Vaporization may be more effective than smoking cannabis
Show		Medical Cannabis Users' Comparisons between Medical Cannabis and Mainstream Medicine.	Cannabis	Many patients substitute their stunning medication by cannabis
Show		Cannabinoid concentrations in confiscated cannabis samples and in whole blood and urine after smoking CBD-rich cannabis as a "tobacco substitute".	Cannabidiol	CBD-rich cannabis legally available in Switzerland may cause positive THC tests on blood and urine
Show	Pain	Impact of Medical Marijuana Legalization on Opioid Use, Chronic Opioid Use, and High-risk Opioid Use.	Cannabis	The legalization of medical cannabis in the USA is associated with lower opioid use
Show		Oral Cannabidiol Use in Children With Autism Spectrum Disorder to Treat Related Symptoms and Co-morbidities.	Cannabis	Cannabis may be helpful in autism
Show		Self-management strategies amongst Australian women with endometriosis: a national online survey.	Cannabis	Cannabis may be highly effective in the self-management of endometriosis according to survey
Show	Pain	Reduction of Benzodiazepine Use in Patients Prescribed Medical Cannabis	Cannabis	Medical cannabis users reduce their intake of benzodiazepines
Show		A randomised controlled trial of vaporised Δ9-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute intoxication effects.		Low doses of CBD increased psychedelic effects of THC and high CBD doses reduced these effects
Show		Medical cannabis patterns of use and substitution for opioids & other pharmaceutical drugs, alcohol, tobacco, and illicit substances; results from a cross-sectional survey of authorized patients.	Cannabis	Cannabis patients reduce the use of other medicinal drugs and alcohol
Show		Recreational marijuana legalization and prescription opioids received by Medicaid enrollees.		Legalisation of cannabis for adult use is associated with reduced opioid use in the USA
Show	Pain	Pills to pot: observational analyses of cannabis substitution among medical cannabis users with chronic pain.	Cannabis	Cannabis may be an effective pain reliever and substitute for opioids according to a survey
Show	Cancer	Cannabis Impacts Tumor Response Rate to Nivolumab in Patients with Advanced Malignancies.	Cannabis	Cannabis may have negative effects on cancer therapy if given together with immunotherapy
Show		On the impact of cannabis consumption on traffic safety: a driving simulator study with habitual cannabis consumers.	Cannabis	In driving simulator tests 3 hours after cannabis consumption there were no longer significant faults.
Show	Pain	Qualifying Conditions Of Medical Cannabis License Holders In The United States.	Cannabis	Chronic pain is the main reason for the medical use of cannabis in the USA
Show	Anxiety	Cannabis use behaviors and prevalence of anxiety and depressive symptoms in a cohort of Canadian medicinal cannabis users.	Cannabis	Cannabis may be helpful in anxiety disorders according to large survey
Show		Marijuana smoking and markers of testicular function among men from a fertility centre	Cannabis	Cannabis use was associated with higher sperm concentration
Show	Cancer	Dronabinol for the Treatment of Paraneoplastic Night Sweats in Cancer Patients: A Report of Five Cases.	Delta-9-THC	THC may reduce night sweats in cancer patients
Show	Cancer	The Prevalence of Nonprescription Cannabinoid-Based Medicines in British Children's Hospices: Results of a National Survey.	Cannabis	Many families use cannabis oil for their children in British hospices
Show	Epilepsy	Cannabidiol in patients with Lennox-Gastaut syndrome: Interim analysis of an open-label extension study.	Cannabidiol	CBD showed long-term efficacy in the treatment of epilepsy due to Lenox-Gastaut syndrome
Show	Psychosis/ schizophrenia	Effect of cannabis on weight and metabolism in first-episode non-affective psychosis: Results from a three-year longitudinal study.	Cannabis	Cannabis use may produce a protective effect against weight gain in psychosis
Show	Cancer	Case Report: Clinical Outcome and Image Response of Two Patients With Secondary High-Grade Glioma Treated With Chemoradiation, PCV, and Cannabidiol.	Cannabidiol	CBD may increase the effects of chemotherapy and radiation in glioblastoma according to case reports
Show		Lower circulating endocannabinoid levels in children with autism spectrum disorder.		Children with autism have lower blood levels of endocannabinoids
Show		Effects of cannabidiol on brain excitation and inhibition systems; a randomised placebo-controlled single dose trial during magnetic resonance spectroscopy in adults with and without autism spectrum disorder.	Cannabidiol	No hint of efficacy of CBD in autism
Show		A quasi-experimental evaluation of marijuana policies and youth marijuana use	Cannabis	Young people may use less cannabis in the US states with medical cannabis laws
Show		The Association between Cannabis Product Characteristics and Symptom Relief.	Cannabis	Medicinal effects of cannabis are mainly based on THC and cannabis flowers were most effective
Show		Spontaneous, anecdotal, retrospective, open-label study on the efficacy, safety and tolerability of cannabis galenical preparation (Bedrocan).	Cannabis	An oral preparation of Bedrocan cannabis showed significant improvement in several chronic diseases
Show	Cancer	Striking lung cancer response to self-administration of cannabidiol: A case report and literature review.	Cannabidiol	CBD and a strong effect on a patient with lung cancer
Show	Gastrointestinal disorder	Cannabis Oil Use by Adolescents and Young Adults With Inflammatory Bowel Disease.	Cannabis	Many young patients with irritable bowel syndrome use cannabis to treat symptoms
Show		Preliminary results from a pilot study examining brain structure in older adult cannabis users and nonusers.	Cannabis	Cannabis use has no relevant effect on the brain on adults
Show	Depression	Marijuana use and major depressive disorder are additively associated with reduced verbal learning and altered cortical thickness.	Cannabis	Cannabis may have negative effects on young people with depression
Show	Asthma	A longitudinal study of cannabis use increasing the use of asthma medication in young Norwegian adults.	Cannabis	Smoking of cannabis may be a risk factor for asthma
Show	Gastrointestinal disorder	Higher odds of irritable bowel syndrome among hospitalized patients using cannabis: a propensity-matched analysis.	Cannabis	Patients with irritable bowel syndrome are more likely to use cannabis
Show	Cancer	Relationship of Cannabis Use to Patient-Reported Symptoms in Cancer Patients Seeking Supportive/Palliative Care.	Cannabis	Many cancer patients treated themselves with cannabis
Show	Gastrointestinal disorder	Cannabinoid Use in Patients With Gastroparesis and Related Disorders: Prevalence and Benefit.	Cannabis	Cannabis may be an effective treatment of delayed gastric emptying according to a survey
Show	Cancer	Impact of Medical Cannabis on Patient-Reported Symptoms for Patients With Cancer Enrolled in Minnesota's Medical Cannabis Program.	Cannabis	Cancer patients report symptom relief by cannabis
Show	Gastrointestinal disorder	Association Between Cannabis Use and Complications Related to Crohn's Disease: A Retrospective Cohort Study.	Cannabis	Cannabis may reduce complications of Crohn’s disease
Show		Illicit drug use and prescription drug misuse among young adult medical cannabis patients and non-patient users in Los Angeles.	Cannabis	The medical use of cannabis was associated with lower probability of illegal drug use in the USA
Show	Gastrointestinal disorder	Members of the endocannabinoid system are distinctly regulated in inflammatory bowel disease and colorectal cancer.	Other cannabinoids	The endocannabinoid system is altered in patients with irritable bowel syndrome and bowel cancer
Show	Depression	Does morning affect contribute to daily Cannabis use?	Cannabis	Cannabis use increases positive affect and reduces anxiety
Show		Employment and Marijuana Use Among Washington State Adolescents Before and After Legalization of Retail Marijuana.	Cannabis	Cannabis use in adolescents decreased in Washington State after legalisation
Show	Depression	Trends of major depressive episode among people with cannabis use: Findings from the National Survey on Drug Use and Health 2006-2015.	Cannabis	Heavy cannabis use is more likely associated with depression
Show	Gastrointestinal disorder; Psychosis/schizophrenia	Cannabis use disorders may protect against certain disorders of the digestive organs in people with schizophrenia but not in healthy controls.	Cannabis	Cannabis use in patients with schizophrenia is associated with a reduced risk for inflammatory bowel disease
Show	Psychosis/schizophrenia	The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study.	Cannabis	High potency cannabis is associated with a higher risk for psychosis
Show		Prescription of a THC/CBD-Based Medication to Patients with Dementia: A Pilot Study in Geneva	Cannabis	Cannabis may improve behaviour in patients with dementia according to observational study
Show	Multiple sclerosis	Multiple Sclerosis and Use of Medical Cannabis: A Retrospective Review Evaluating Symptom Outcomes	Cannabis	MS patients taking cannabis were able to reduce intake of opioids and benzodiazepines
Show	Posttraumatic stress disorder	Loss of exercise- and stress-induced increases in circulating 2-arachidonoylglycerol concentrations in adults with chronic PTSD.	Other cannabinoids	The endocannabinoid system shows a reduced activity in patients with post-traumatic stress disorder
Show	Depression	Serum Endocannabinoid and Mood Changes after Exercise in Major Depressive Disorder.		Endocannabinoids contribute to the mood improving effects of exercise in patients with major depression
Show	Dependency/ withdrawal	The relationship between motivations for cannabis consumption and problematic use.	Cannabis	The risk for problematic use of cannabis depends on reason for use
Show	Gastrointestinal disorder	Palmitoylethanolamide and Cannabidiol Prevent Inflammation-induced Hyperpermeability of the Human Gut In Vitro and In Vivo-A Randomized, Placebo-controlled, Double-blind Controlled Trial.	Cannabidiol	CBD and palmitoylethanolamine may be helpful in inflammatory bowel disease
Show	Epilepsy	Pharmacokinetics and Tolerability of Multiple Doses of Pharmaceutical-Grade Synthetic Cannabidiol in Pediatric Patients with Treatment-Resistant Epilepsy.	Cannabidiol	CBD may influence the blood concentrations of antiepileptic drugs
Show	Epilepsy	Higher cannabidiol plasma levels are associated with better seizure response following treatment with a pharmaceutical grade cannabidiol.	Cannabidiol	Efficacy of CBD in epilepsy is correlated to blood levels
Show	Dependency/ withdrawal	Cannabidiol for the Reduction of Cue-Induced Craving and Anxiety in Drug-Abstinent Individuals With Heroin Use Disorder: A Double-Blind Randomized Placebo-Controlled Trial.	Cannabidiol	CBD reduces craving in drug-abstinence individuals with heroin dependency according to clinical study
Show		Medical marijuana laws are associated with increases in substance use treatment admissions by pregnant women.	Cannabis	Legalisation of cannabis for medical use in the US increased cannabis use by pregnant women
Show		Cannabis use as a risk factor for causing motor vehicle crashes: a prospective study.	Cannabis	Non-significant increase of crash risk in drivers under the influence of cannabis
Show	Cancer	Medical Cannabis Use in Glioma Patients Treated at a Comprehensive Cancer Center in Florida.	Cannabis	Many patients with brain cancer use cannabis
Show		Lifetime marijuana use in relation to insulin resistance in lean, overweight and obese U.S. adults		Cannabis may have a protective effects against diabetes in obese individuals
Show		The association between cannabis use and psychiatric comorbidity in people with personality disorders: A population-based longitudinal study.		Cannabis users with personality disorders are not at increased risk for developing other psychiatric disorders
Show		The influence of substance use on the effectiveness of antipsychotic medication: a prospective, pragmatic study.		Cannabis had no influence on the efficacy of antipsychotic medication
Show	Pain	Medical Cannabis: Effects on Opioid and Benzodiazepine Requirements for Pain Control.		Cannabis reduces opioid use by pain patients
Show	Epilepsy	Cannabis Use Disorder and Epilepsy: A Cross-National Analysis of 657 072 Hospitalized Patients	Cannabis	The use of cannabis, tobacco and alcohol is associated with higher prevalence of epilepsy
Show	Depression	Depression and marijuana use disorder symptoms among current marijuana users	Cannabis	People with depression more often use cannabis
Show		Investigating the Relationships Between Alcohol Consumption, Cannabis Use, and Circulating Cytokines: A Preliminary Analysis	Cannabis	Cannabinoid compounds may serve to mitigate inflammation associated with alcohol use
Show	Pain	Patient Perceptions of the Use of Medical Marijuana in the Treatment of Pain After Musculoskeletal Trauma: A Survey of Patients at 2 Trauma Centers in Massachusetts.	Cannabis	Patients believe that medical marijuana is a valid treatment and that it does have a role in reducing postinjury and postoperative pain.
Show		Cannabis use is associated with reduced prevalence of progressive stages of alcoholic liver disease.	Cannabis	Cannabis use may be associated with a reduced incidence of liver disease in alcoholics
Show	HIV/AIDS;Pain	Cannabis Use is Associated with Lower Odds of Prescription Opioid Analgesic Use Among HIV-Infected Individuals with Chronic Pain	Cannabis	Medical cannabis legislation might reduce the need for opioid analgesics for pain management
Show		A Prospective Study of Humoral and Cellular Immune Responses to Hepatitis B Vaccination in Habitual Marijuana Smokers	Cannabis
Show		Marijuana Use and Renal Function Among US Adults	Cannabis
Show		Cannabidiol Based Medical Cannabis in Children with Autism- a Retrospective Feasibility Study	Cannabis;Cannabidiol	A CBD-rich cannabis extract may be effective in children with autism
Show	Dependency /withdrawal	Cannabidiol reverses attentional bias to cigarette cues in a human experimental model of tobacco withdrawal	Cannabidiol	CBD may be helpful in tobacco dependency
Show		Marijuana Use Associations with Pulmonary Symptoms and Function in Tobacco Smokers Enrolled in the Subpopulations and Intermediate Outcome Measures in COPD Study	Cannabis	Cannabis use is not associated with increased risks of respiratory diseases.
Show		Marijuana use and fecundability in a North American preconception cohort study	Cannabis
Show		Caloric restriction lowers endocannabinoid tonus and improves cardiac function in type 2 diabetes		Caloric restriction in patients with type 2 diabetes reduces endocannabinoid levels
Show		The Grass Might Be Greener: Medical Marijuana Patients Exhibit Altered Brain Activity and Improved Executive Function after 3 Months of Treatment	Cannabis	The medical use of cannabis improves cognitive performance
Show		Epidemiological characteristics, safety and efficacy of medical cannabis in the elderly	Cannabis	The medical use of cannabis is safe in elder people
Show	Rare diseases	Cannabidiol in patients with seizures associated with Lennox-Gastaut syndrome (GWPCARE4): a randomised, double-blind, placebo-controlled phase 3 trial	Cannabidiol	CBD is effective against seizures in Lennox-Gastaut syndrome
Show	HIV/AIDS	Heavy Cannabis Use Associated With Reduction in Activated and Inflammatory Immune Cell Frequencies in Antiretroviral Therapy-Treated Human Immunodeficiency Virus-Infected Individuals	Cannabis	Heavy cannabis use in patients with HIV is associated with improved immune function
Show	Cancer	Prospective analysis of safety and efficacy of medical cannabis in large unselected population of patients with cancer	Cannabis	Cannabis is effective in alleviating symptoms of cancer patients
Show	Pain	Medical Cannabis for the Treatment of Fibromyalgia	Cannabis	Cannabis may have a beneficial effect on patients with fibromyalgia
Show	Pain	Impact of co-administration of oxycodone and smoked cannabis on analgesia and abuse liability	Cannabis	Cannabis enhances the pain reducing effects of the opioid oxycodone according to experimental study
Show	Epilepsy	Cannabidiol for treatment of refractory childhood epilepsies: Experience from a single tertiary epilepsy center in Slovenia	Cannabidiol	About half of children with epilepsy had a significant improvement following CBD treatment
Show	Spinal cord injury	Cannabis Use in Individuals With Spinal Cord Injury or Moderate to Severe Traumatic Brain Injury in Colorado	Cannabis	A high number of patients with spinal cord injury and traumatic brain injury use cannabis
Show	Rare diseases	Randomized, dose-ranging safety trial of cannabidiol in Dravet syndrome	Cannabidiol	The use of CBD in children has only minimal effects on other antiepileptic drugs
Show		Beneficial Effect of Medical Cannabis in the Treatment of a Pharmacoresistant Nausea Associated with a Somatoform Disorder in a Patient with Post-Polio Syndrome	Cannabis	Cannabis improved nausea in a patient with post-polio syndrome
Show		Marijuana use and mortality following orthopedic surgical procedures.	Cannabis	Cannabis use was associated with reduced mortality following orthopaedic surgery
Show	Appetite loss/weight loss;Cancer	The effect of nabilone on appetite, nutritional status, and quality of life in lung cancer patients: a randomized, double-blind clinical trial	Nabilone	Nabilone improved appetite in cancer patients in a controlled clinical study
Show	Pain	Chronic Pain Treatment With Cannabidiol in Kidney Transplant Patients in Uruguay	Cannabidiol	CBD may reduce pain in patients with kidney transplants
Show	Huntington's disease	Cannabinoids for Treatment of Dystonia in Huntington's Disease	Other cannabinoids	Cannabinoids may be helpful in the treatment of Huntington's disease
Show		Plasma anandamide concentrations are lower in children with autism spectrum disorder		In patients with autism there are low blood concentrations of anandamide
Show		Effect of cannabis and tobacco on emphysema in patients with spontaneous pneumothorax	Cannabis	Cannabis use may accelerate the development of emphysema in tobacco smokers
Show	Pain	Association of Medical and Adult-Use Marijuana Laws With Opioid Prescribing for Medicaid Enrollees	Cannabis	Legalization of cannabis for medical use is associated with reduced prescriptions of opioids
Show	Pain	Association Between US State Medical Cannabis Laws and Opioid Prescribing in the Medicare Part D Population	Cannabis	Legalization of cannabis for medical use is associated with reduced prescriptions of opioids
Show		A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis	Cannabidiol	A CBD-rich cannabis extract improved symptoms of ulcerative colitis in a controlled clinical study
Show		A Randomized, Double-blind, Placebo-controlled, Parallel-group, Pilot Study of Cannabidiol-rich Botanical Extract in the Symptomatic Treatment of Ulcerative Colitis	Cannabidiol	A CBD-rich cannabis extract improved symptoms of ulcerative colitis in a controlled clinical study
Show	Psychosis/ schizophrenia	The effects of cannabidiol (CBD) on cognition and symptoms in outpatients with chronic schizophrenia a randomized placebo controlled trial	Cannabidiol	CBD did not improve cognition in patients with schizophrenia
Show	Anxiety;Pain; Sleep disorder	Substitution of medical cannabis for pharmaceutical agents for pain, anxiety, and sleep	Cannabis	Patients who use cannabis reduce their use in medications for pain, anxiety, migraine and sleep disorders
Show	Pain	Effects of Legal Access to Cannabis on Scheduled II-V Drug Prescriptions.	Cannabis	Legal access to cannabis may reduce the treatment with other medicinal drugs
Show	Cancer;Pain	Results of a Double-Blind, Randomized, Placebo-Controlled Study of Nabiximols Oromucosal Spray as an Adjunctive Therapy in Advanced Cancer Patients with Chronic Uncontrolled Pain	Other cannabinoids	Low effects of a cannabis extract in cancer patients in a large controlled study
Show	Multiple sclerosis	THC/CBD oromucosal spray in patients with multiple sclerosis overactive bladder: a pilot prospective study	Other cannabinoids	Cannabis may be beneficial in overactive bladder of patients with MS according to an observational study
Show	HIV/AIDS	Daily cannabis and reduced risk of steatosis in human immunodeficiency virus and hepatitis C virus-co-infected patients	Cannabis	Daily cannabis use may protect the liver in people with HIV and hepatitis C
Show	HIV/AIDS	Association of Cannabis, Stimulant, and Alcohol use with Mortality Prognosis Among HIV-Infected Men	Cannabis	Cannabis use has no effect on the mortality of HIV-infected men
Show	Pain	Patterns and correlates of medical cannabis use for pain among patients prescribed long-term opioid therapy	Cannabis	Cannabis use in pain patients was associated with a higher risk for opioid misuse
Show	HIV/AIDS	HIV-infected cannabis users have lower circulating CD16+ monocytes and IFN-γ-inducible protein 10 levels compared with nonusing HIV patients	Cannabis	Cannabis may slow inflammation of the brain in patients with HIV and may maintain cognitive performance
Show	Psychosis/ schizophrenia	Cannabidiol (CBD) as an Adjunctive Therapy in Schizophrenia: A Multicenter Randomized Controlled Trial	Cannabidiol	Cannabidiol may be helpful in schizophrenia according to clinical study
Show	Sleep disorder	Pharmacotherapy of Apnea by Cannabimimetic Enhancement, the PACE Clinical Trial: Effects of Dronabinol in Obstructive Sleep Apnea	Other cannabinoids	THC may be effective in the treatment of sleep apnoea according to a clinical study
Show		Marijuana Use is Protective in Burns	Cannabis	Cannabis use reduces mortality in patients with burns
Show	Epilepsy	Efficacy of CBD-enriched medical cannabis for treatment of refractory epilepsy in children and adolescents – An observational, longitudinal study	Cannabis	A cannabis extract with THC and CBD reduced seizures in epilepsy
Show	Anxiety;Depression	A naturalistic examination of the perceived effects of cannabis on negative affect	Cannabis	Acute use of cannabis may reduce anxiety and depression
Show		No Acute Effects of Cannabidiol on the Sleep-Wake Cycle of Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled, Crossover Study	Cannabidiol	CBD may be used against anxiety and depression without altering normal sleep
Show		Relation of Cannabis Use and Atrial Fibrillation Among Patients Hospitalized for Heart Failure	Cannabis	Cannabis use was associated with a lower risk of artrial fibrillation
Show	Dependency/ withdrawal	The effect of high-dose dronabinol (oral THC) maintenance on cannabis self-administration	Delta-9-THC	High doses of oral THC reduced intake of inhaled THC
Show		Testing associations between cannabis use and subcortical volumes in two large population-based samples		Cannabis use has no effect on brain structure
Show		Prolonged Cannabidiol Treatment Effects on Hippocampal Subfield Volumes in Current Cannabis Users	Cannabis	CBD repaired negative effects of regular cannabis use on a certain brain region
Show		Endocannabinoid system in systemic lupus erythematosus: First evidence for a deranged 2-arachidonoylglycerol metabolism	Other cannabinoids	Systemic lupus erythematosus was associated with an altered endocannabinoid system
Show	Pain	Effect profile of paracetamol, Δ9-THC and promethazine using an evoked pain test battery in healthy subjects	Delta-9-THC	Acute pain is reduced by THC
Show		Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis	Cannabis	Effects of cannabis on cognitive performance in adolescents are small
Show		Effect of Cannabidiol on Drop Seizures in the Lennox-Gastaut Syndrome	Cannabidiol
Show	Dependency/ withdrawal	The effects of cannabidiol on impulsivity and memory during abstinence in cigarette dependent smokers.	Cannabidiol
Show	Pain	Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort.	Cannabis	Pain patients often substitute opioids with cannabis
Show		Palmitoylethanolamide as adjunctive therapy for autism: Efficacy and safety results from a randomized controlled trial.	Other cannabinoids
Show	Multiple sclerosis	Sativex® as Add-on therapy Vs. further optimized first-line ANTispastics (SAVANT) in resistant multiple sclerosis spasticity: a double-blind, placebo-controlled randomised clinical trial.	Other cannabinoids	Long-term efficacy of a cannabis spray in the treatment of spasticity due to multiple sclerosis
Show	Multiple sclerosis	Effect of tetrahydrocannabinol:cannabidiol oromucosal spray on activities of daily living in multiple sclerosis patients with resistant spasticity: a retrospective, observational study.	Other cannabinoids	A cannabis spray has positive effects on activities of daily living in patients with Multiple Sclerosis
Show	Pain	The relationship of endocannabinoidome lipid mediators with pain and psychological stress in women with fibromyalgia – a case control study	Other cannabinoids	Fibromyalgia is associated with increased blood levels of endocannabinoids
Show	Psychosis/ schizophrenia	The association between cannabis use and suicidal behavior in patients with psychiatric disorders: an analysis of sex differences	Cannabis	Cannabis use has no effect on suicidal attempts in psychiatric disorders
Show		Self-initiated use of topical cannabidiol oil for epidermolysis bullosa	Cannabidiol
Show		Endocannabinoid receptor CB2R is significantly expressed in aspirin-exacerbated respiratory disease: a pilot study	Other cannabinoids	The number of CB2 receptors is increased in a certain respiratory disease
Show	Multiple sclerosis ;Pain	Pain Modulation after Oromucosal Cannabinoid Spray (SATIVEX®) in Patients with Multiple Sclerosis: A Study with Quantitative Sensory Testing and Laser-Evoked Potentials.	Other cannabinoids	Cannabis reduces pain in multiple sclerosis
Show	Pain	Preliminary evaluation of the efficacy, safety, and costs associated with the treatment of chronic pain with medical cannabis.	Cannabis	Cannabis reduces pain and increases the quality of life in pain patients
Show	Cancer	Many cancer patients use cannabis in Canada	Cannabis	Many cancer patients use cannabis in Canada
Show	Posttraumatic stress disorder	Cannabis Use Disorder and Post-Deployment Suicide Attempts in Iraq/Afghanistan-Era Veterans	Cannabis	Cannabis dependence was associated with an increased risk of suicide in war veterans
Show	Pain	Medical Cannabis Legalization and Opioid Prescriptions: Evidence on US Medicaid Enrollees during 1993-2014.	Cannabis	Legalization of cannabis for medical use in the US is associated with reduced opioid prescriptions
Show		Marijuana use and short-term outcomes in patients hospitalized for acute myocardial infarction	Cannabis	Cannabis use is associated with decreased mortality in hospital after a heart attack
Show	Epilepsy	Open-label use of Highly* purified CBD (Epidiolex®) in patients with CDKL5 deficiency disorder and Aicardi, Dup15q, and Doose syndromes.	Cannabidiol	CBD reduces seizures in several further childhood-onset epilepsy forms according to an open-label study
Show	Multiple sclerosis	Tetrahydrocannabinol/Cannabidiol Oromucosal Spray in Patients With Multiple Sclerosis: A Pilot Study on the Plasma Concentration-Effect Relationship.	Delta-9-THC;Cannabidiol	Large variation of plasma concentrations of THC and CBD after oral intake
Show	Epilepsy	Long-term safety and treatment effects of cannabidiol in children and adults with treatment-resistant epilepsies: Expanded access program results.	Cannabidiol	CBD was effective in several epilepsy forms in the long-term
Show	Sleep disorder	Effectiveness of Raw, Natural Medical Cannabis Flower for Treating Insomnia under Naturalistic Conditions.	Cannabis	The effect of cannabis on insomnia depended on the cannabis variety
Show	Pain	Effect of cannabis use in people with chronic non-cancer pain prescribed opioids: findings from a 4-year prospective cohort study.	Cannabis	Pain patients who use cannabis have greater pain severity than non-users
Show		Marijuana Use in Adults Living with Sickle Cell Disease.	Cannabis	Cannabis may have therapeutic effects in patients with sickle cell disease
Show	Anxiety;Depression; Pain;Sleep disorder	A Cross-Sectional Study of Cannabidiol Users.	Cannabidiol	CBD is mostly used against pain, sleep disorders, anxiety and depression
Show	Pain	Marijuana's Influence on Pain Scores, Initial Weight Loss, and Other Bariatric Surgical Outcomes.	Cannabis	Cannabis users need higher doses of opioids after surgery
Show	Alzheimer's disease	Treating non-cognitive symptoms of people with dementia	Delta-9-THC	Nabilone improves agitation and other behavioural symptoms in patients with Alzheimer’s disease
Show	Epilepsy	Composition and Use of Cannabis Extracts for Childhood Epilepsy in the Australian Community	Cannabis	THC and CBD content in products used for self-treatment of Australian children with epilepsy varies considerably
Show	Tourette's syndrome	Pure delta-9-tetrahydrocannabinol and its combination with cannabidiol in treatment-resistant Tourette syndrome: A case report.	Delta-9-THC;Cannabidiol	A case report suggests that CBD may be beneficial in Tourette syndrome
Show		Long-Term Heavy Recreational Cannabis Use and Serum Delta-9-Tetrahydrocannabinol Levels are not Associated with an Impaired Liver Function in Cannabis Dependents.	Cannabis	Heavy cannabis use has no relevant influence on liver function
Show	Cancer chemotherapy	Safety and efficacy of nabilone for acute chemotherapy-induced vomiting prophylaxis in pediatric patients: A multicenter, retrospective review.	Delta-9-THC	Nabilone is well tolerated in children undergoing chemotherapy
Show		Medical marijuana laws and workplace fatalities in the United States.	Cannabis	Medical cannabis laws in the USA are associated with improved workplace safety
Show	Dependency/ withdrawal	Falling rates of marijuana dependence among heavy users.	Cannabis	The risk of dependence formation among heavy cannabis users in the USA declined in the past 15 years
Show	Epilepsy	Cannabidiol improves frequency and severity of seizures and reduces adverse events in an open-label add-on prospective study.	Cannabidiol	Large study with CBD in patients with epilepsy demonstrates good long-term safety of the medication
Show	Cancer	Current natural therapies in the treatment against glioblastoma.	Cannabis	Cannabinoids may be helpful in glioblastoma
Show	Epilepsy	Cannabidiol for treating drug-resistant epilepsy in children: the New South Wales experience.	Cannabidiol	CBD effective in children with epilepsy
Show		Medicinal cannabis in Australia, 2016: the Cannabis as Medicine Survey (CAMS-16).	Cannabis	Results of a survey among Australian patients, who treat themselves with cannabis
Show	Pain	Self-Reported Effectiveness and Safety of Trokie® Lozenges: A Standardized Formulation for the Buccal Delivery of Cannabis Extracts.	Cannabis	Cannabis lozenges reduce pain in an observational study
Show		Decreased Cannabinoid CB1 Receptors in Male Tobacco Smokers Examined With Positron Emission Tomography.		Tobacco smokers have reduced concentrations of brain CB1 receptors
Show		The Association Between Tetrahydrocannabinol and Lower Urinary Tract Symptoms Utilizing the National Health and Nutrition Examination Survey.	Delta-9-THC	Cannabis use is protective against lower urinary tract symptoms
Show	Pain	The Consumption of Cannabis by Fibromyalgia Patients in Israel.	Cannabis	Many patients with fibromyalgia profit from a treatment with cannabis according to survey
Show	Psychosis/ schizophrenia	Impact of substance use disorder on gray matter volume in schizophrenia.	Cannabis	Cannabis use does not influence gray matter of the brain in schizophrenia
Show	Psychosis/ schizophrenia	GWAS of lifetime cannabis use reveals new risk loci, genetic overlap with psychiatric traits, and a causal influence of schizophrenia.	Cannabis	Genetic investigation shows positive influence of schizophrenia risk on cannabis use
Show		Cannabinoid concentrations in blood and urine after smoking cannabidiol joints.	Cannabidiol	CBD blood concentrations after smoking CBD cigarettes
Show	Pain		Cannabis	Cannabis use was associated with less pain after orthopaedic surgery
Show	Pain	Cannabis analgesia in chronic neuropathic pain is associated with altered brain connectivity.	Delta-9-THC	THC reduces neuropathic pain and this is associated with altered connections between two brain regions
Show		Patient-Reported Symptom Relief Following Medical Cannabis Consumption	Cannabis	Cannabis provides symptom relief in a wide range of health conditions
Show		Association between the detection of alcohol, illicit drugs and/or psychotropic medications/opioids in patients admitted due to trauma and trauma recidivism: A cohort study.	Cannabis	Alcohol and cannabis use was associated with an increased risk of re-injury
Show		Association and Clinical Outcomes of Marijuana in Patients with Intracerebral Hemorrhage.	Cannabis	Cannabis use does not increase the risk of stroke due to bleeding in the brain
Show	Dependency /withdrawal	High-intensity cannabis use is associated with retention in opioid agonist treatment: a longitudinal analysis.	Cannabis	Drug addicts have higher retention to opioid replacement treatment if they use cannabis
Show	Epilepsy	A prospective open-label trial of a CBD/THC cannabis oil in dravet syndrome	Delta-9-THC;Cannabidiol	Cannabis extract with high CBD and low THC content effective in childhood epilepsy
Show	Pain	Cannabinoids and spinal cord stimulation for the treatment of failed back surgery syndrome refractory pain.	Delta-9-THC;Cannabidiol	Cannabis improves pain in patients with failed back surgery syndrome
Show	Appetite loss/ weight loss	Efficacy and Safety of Appetite-Stimulating Medications in the Inpatient Setting	Delta-9-THC	No difference on reduced appetite between THC, megestrol and mirtazapine
Show		Joint culpability: The effects of medical marijuana laws on crime	Cannabis	Medical cannabis laws in the USA not associated with crime
Show	Attention-deficit/hyperactivity disorder	ADHD, depression, and substance abuse risk among beginning college students.	Cannabis	Students with ADHD are more likely to use cannabis
Show		Circulating Endocannabinoids Are Reduced Following Bariatric Surgery and Associated with Improved Metabolic Homeostasis in Humans	Other cannabinoids	Endocannabinoid levels in obese patients were reduced after surgery against obesity
Show		The relationship between cannabis use and diabetes: Results from the National Epidemiologic Survey on Alcohol and Related Conditions III	Cannabis	Cannabis use is associated with significant reduction in occurrence of diabetes
Show	Tourette's syndrome	Single center experience with medical cannabis in Gilles de la Tourette syndrome	Cannabis	Cannabis is effective in Tourette syndrome according to a survey
Show	Cancer	Report of Objective Clinical Responses of Cancer Patients to Pharmaceutical-grade Synthetic Cannabidiol	Cannabidiol	Cannabidiol may be useful in the treatment of cancer according to an observational study
Show	Dependency/ withdrawal	Exploring the association of legalisation status of cannabis with problematic cannabis use and impulsivity in the USA.	Cannabis	The status of legalisation in US states has no effect on problematic cannabis use
Show	Dependency/ withdrawal; Depression	Sex Differences in the Association Between Cannabis Use and Suicidal Ideation and Attempts, Depression, and Psychological Distress Among Canadians.	Cannabis	Cannabis use may be associated with an increased risk of suicide
Show	Dependency/ withdrawal	DSM-5 cannabis withdrawal syndrome: Demographic and clinical correlates in U.S. adults	Cannabis	Cannabis withdrawal syndrome is found in 12% of frequent users
Show	Pain	The Impact of Cannabis Access Laws on Opioid Prescribing	Cannabis	Cannabis laws in the USA are associated with reduced opioid prescriptions
Show		Reduced Incidence and Better Liver Disease Outcomes among Chronic HCV Infected Patients Who Consume Cannabis	Cannabis	Cannabis reduces risk of liver cirrhosis in patients with hepatitis C virus infection
Show	Pain	Combined THC and CBD to treat pain in epidermolysis bullosa: a report of three cases.	Delta-9-THC;Cannabidiol	Cannabis effective against pain due to epidermolysis bullosa according to case reports
Show	Cancer;Cancer chemotherapy	Medical Cannabis Use by Hodgkin Lymphoma Patients: Experience of a Single Center	Cannabis	Patients with Hodgkin’s lymphoma may profit from a treatment with cannabis
Show		Brief Report: Cannabidiol-Rich Cannabis in Children with Autism Spectrum Disorder and Severe Behavioral Problems-A Retrospective Feasibility Study.	Cannabidiol	Cannabis may be helpful in the treatment of children with autism in an open study
Show	Epilepsy	Efficacy of cannabinoids in paediatric epilepsy	Cannabidiol	CBD is similar effective as established antiepileptic drugs
Show	Dependency/ withdrawal	A Survey of Cannabis Acute Effects and Withdrawal Symptoms: Differential Responses Across User Types and Age.	Cannabis	Differences between medical and recreational cannabis users with regard to withdrawal
Show	Pain	Effect of adding medical cannabis to analgesic treatment in patients with low back pain related to fibromyalgia: an observational cross-over single centre study.	Cannabis	Cannabis may be beneficial in patients with fibromyalgia and low back pain
Show		Should donors who have used marijuana be considered candidates for living kidney donation?	Cannabis	Cannabis users may be kidney donors
Show	Dependency/ withdrawal	Greater risk for frequent marijuana use and problems among young adult marijuana users with a medical marijuana card.	Cannabis	Adolescents, who are allowed to use medical cannabis, use cannabis more often
Show			Cannabis	Smoking of cannabis may promote airway inflammation
Show		Effects of chronic marijuana use on driving performance	Cannabis	Regular cannabis users had lower driving abilities
Show	Amyotrophic lateral sclerosis;Spasticity	Safety and efficacy of nabiximols on spasticity symptoms in patients with motor neuron disease (CANALS): a multicentre, double-blind, randomised, placebo-controlled, phase 2 trial.		Cannabis is effective in spasticity due to amyotrophic lateral sclerosis
Show	Posttraumatic stress disorder	Cannabidiol in the Treatment of Post-Traumatic Stress Disorder: A Case Series.	Cannabidiol	CBD may be beneficial in the post-traumatic stress disorder according to case series
Show		Reduced Prevalence of Alcoholic Gastritis in Hospitalized Individuals Who Consume Cannabis	Cannabis	Cannabis reduces the risk for alcohol-associated gastritis
Show		Cortical surface morphology in long-term cannabis users: A multi-site MRI study.	Cannabis	Cannabis use not associated with structure of the brain’s cortex
Show		Disentangling longitudinal relations between youth cannabis use, peer cannabis use, and conduct problems: developmental cascading links to cannabis use disorder.	Cannabis	Cannabis use does not increase conduct problems in young people
Show	Epilepsy	Long-Term Safety, Tolerability, and Efficacy of Cannabidiol in Children with Refractory Epilepsy: Results from an Expanded Access Program in the US.	Cannabidiol	Long-term observation of children with epilepsy treated with CBD
Show		A meta-analysis of the crash risk of cannabis-positive drivers in culpability studies-Avoiding interpretational bias.	Cannabis	The risk for traffic accidents caused by cannabis is low
Show		Aerobic Fitness Level Moderates the Association Between Cannabis Use and Executive Functioning and Psychomotor Speed Following Abstinence in Adolescents and Young Adults.	Cannabis	Negative effects of cannabis use on cognition in young people is lower in those with good physical fitness
Show		Reduced Risk of Alcohol-Induced Pancreatitis With Cannabis Use.	Cannabis	Cannabis use is associated with a reduced risk for alcohol-associated pancreatitis
Show	Multiple sclerosis	Exploring cannabis use by patients with multiple sclerosis in a state where cannabis is legal.	Cannabis	Many patients with multiple sclerosis use cannabis, if it is legal
Show		Subregional Hippocampal Thickness Abnormalities in Older Adults with a History of Heavy Cannabis Use.	Cannabis	Cannabis users have lower cortical thickness of the hippocampus in the brain
Show	Posttraumatic stress disorder	Remission of severe, treatment-resistant schizophrenia following adjunctive cannabidiol	Cannabidiol	CBD effective in treatment-resistant schizophrenia according to a case report
Show	Pain	An experimental randomized study on the analgesic effects of pharmaceutical-grade cannabis in chronic pain patients with fibromyalgia.	Cannabis	Cannabis rich in THC may be useful in the treatment of fibromyalgia
Show		Associations between cannabis use and cardiometabolic risk factors: A longitudinal study of men.	Cannabis	Cannabis use is associated with lower risk for factors associated with diseases of heart and blood vessels
Show	Epilepsy	Successful use of pure cannabidiol for the treatment of super-refractory status epilepticus.	Cannabidiol	CBD may be effective in refractory status epilepticus according to a case report
Show	Cancer	Cannabinoid receptor expression in estrogen-dependent and estrogen-independent endometrial cancer.	Other cannabinoids	Cannabinoid receptors may be therapeutic targets in the treatment or prevention of endometrial cancer
Show	Inflammation	Investigating the Relationships Between Alcohol Consumption, Cannabis Use, and Circulating Cytokines: A Preliminary Analysis	Cannabis	Cannabis use mitigates inflammation associated with alcohol use
Show	Attention-deficit/hyperactivity disorder	Cannabinoids in attention-deficit/hyperactivity disorder: a randomised-controlled trial	Other cannabinoids	Cannabis reduced symptoms of ADHD in a small clinical study
Show	Pain	Cannabis and intractable chronic pain: an explorative retrospective analysis of Italian cohort of 614 patients	Cannabis;Other cannabinoids	Cannabis may be effective in the treatment of chronic pain according to a large case series from Italy
Show		A single dose of cannabidiol reduces blood pressure in healthy volunteers in a randomized crossover study	Cannabidiol	CBD reduces blood pressure in healthy people
Show	Cancer	Medical Cannabis in the Palliation of Malignant Wounds—A Case Report	Cannabis	Topical application of a cannabis extract helpful in cancer wound
Show	Multiple sclerosis	Cannabis and cognitive functioning in multiple sclerosis: The role of gender	Cannabis	Cannabis use may have a negative effect on cognition in male patients with multiple sclerosis
Show		Cannabis, Tobacco, Alcohol Use, and the Risk of Early Stroke: A Population-Based Cohort Study of 45 000 Swedish Men	Cannabis	Cannabis use does not increase the risk of stroke in young people, while tobacco does
Show	Pain	Cannabinoids as effective as pharmaceutical treatments for migraine attacks	Other cannabinoids	Cannabis effective in migraine and cluster headache in a clinical study
Show	Inflammation	Potent immunomodulatory activity of a highly selective cannabinoid CB2 agonist on immune cells from healthy subjects and patients with multiple sclerosis		Activation of the CB2 receptor counteracts inflammation of nerve cells
Show		Moderate and vigorous physical activity patterns among marijuana users: Results from the 2007-2014 National Health and Nutrition Examination Surveys	Cannabis	Cannabis use was associated with reduced recreational physical activity
Show		Association of State Recreational Marijuana Laws With Adolescent Marijuana Use	Cannabis	Mixed consequences of cannabis legalization on cannabis use by adolescents
Show		How does marijuana affect outcomes after trauma in ICU patients? A propensity-matched analysis	Cannabis	Cannabis use may decrease mortality in trauma patients
Show	Cancer;Pain	Sativex oromucosal spray as adjunctive therapy in advanced cancer patients with chronic pain unalleviated by optimized opioid therapy: two double-blind, randomized, placebo-controlled phase 3 studies.	Cannabidiol;Other cannabinoids	A cannabis extract did not reduce pain in advanced cancer patients, who did not respond to opioids
Show	Tourette's syndrome	Speechlessness in Gilles de la Tourette Syndrome: Cannabis-Based Medicines Improve Severe Vocal Blocking Tics in Two Patients	Cannabis;Delta-9-THC	Speechlessness in Tourette syndrome may be treated with cannabis/THC according to case reports
Show	Pain	Perioperative Patient Beliefs Regarding Potential Effectiveness of Marijuana (Cannabinoids) for Treatment of Pain: A Prospective Population Survey	Cannabis	More than 80% of patients believe that cannabis may reduce pain
Show	Epilepsy	Interactions between cannabidiol and commonly used antiepileptic drugs	Cannabidiol	: CBD interacts with other anti-epileptic drugs
Show	Spinal cord injury	Cannabis use in persons with traumatic spinal cord injury in Denmark	Cannabis	Cannabis use is more frequent among people with spinal cord injury than among the general population
Show	Pain	Topical Medical Cannabis: A New Treatment for Wound Pain-Three Cases of Pyoderma Gangrenosum	Cannabis	Topical cannabis reduced wound pain in a small case series
Show	HIV/AIDS	Confirmed marijuana use and lymphocyte count in black people living with HIV	Cannabis	Cannabis has no negative effect on the immune system in patients with HIV
Show	Spinal cord injury	Delta-9-tetrahydrocannabinol-cannabidiol in the treatment of spasticity in chronic spinal cord injury: a clinical experience	Other cannabinoids	Cannabis may be helpful in patients with spinal cord injuries according to an observational study
Show	Appetite loss/weight loss	Association Between Use of Cannabis in Adolescence and Weight Change into Midlife	Cannabis	Cannabis use during adolescence not associated with weight in midlife
Show	Anxiety	Association of cannabis use with the development of elevated anxiety symptoms in the general population: a meta-analysis	Cannabis	No relevant association between cannabis use and anxiety in the general population
Show		Effect of food on the pharmacokinetics of dronabinol oral solution versus dronabinol capsules in healthy volunteers	Other cannabinoids	Maximum blood concentrations after oral intake of THC were reached faster in a fasted state than in if taken together with a meal
Show	Pain	Patient Perceptions of the Use of Medical Marijuana in the Treatment of Pain After Musculoskeletal Trauma: A Survey of Patients at 2 Trauma Centers in Massachusetts	Cannabis;Other cannabinoids	Trauma patients find relief from a treatment with cannabis according to a survey
Show	Parkinson's disease	Cannabis use in people with Parkinson's disease and Multiple Sclerosis: A web-based investigation	Cannabis	Cannabis may be helpful in Parkinson’s disease according to a survey
Show	Amyotrophic lateral sclerosis	Co-medication with Cannabidiol May Slow Down the Progression of Motor Neuron Disease: A Case Report	Cannabidiol	Cannabidiol slowed progression of amyotrophic lateral sclerosis in a case report
Show		Evaluation of divided attention psychophysical task performance and effects on pupil sizes following smoked, vaporized and oral cannabis administration	Cannabis	Effects of inhaled and oral THC on pupil size and psychomotor performance
Show		Cannabis for restless legs syndrome: a report of six patients	Cannabis	Cannabis may be helpful in restless legs syndrome according to case reports
Show		Smoked marijuana attenuates performance and mood disruptions during simulated night shift work	Cannabis	The use of cannabis improves performance during simulated night shift work
Show	Psychosis/ schizophrenia	Cannabis use and psychotic-like experiences trajectories during early adolescence: the coevolution and potential mediators	Cannabis	Cannabis use in adolescents was associated with psychotic-like experiences
Show	Psychosis/ schizophrenia	Effect of continued cannabis use on medication adherence in the first two years following onset of psychosis	Cannabis	Heavy cannabis use may reduce adherence to medication in patients with psychosis
Show	Multiple sclerosis ;Spasticity	Effects on Spasticity and Neuropathic Pain of an Oral Formulation of Δ9-Tetrahydrocannabinol in Patients With Progressive Multiple Sclerosis.	Delta-9-THC	THC showed mixed results in the treatment of pain and spasticity in multiple sclerosis
Show		Randomised clinical trial: the analgesic properties of dietary supplementation with palmitoylethanolamide and polydatin in irritable bowel syndrome		A treatment with palmithoylethanolamide and polydatin improved pain in irritable bowel syndrome
Show	Nausea/vomiting	A randomized-controlled trial of nabilone for the prevention of acute postoperative nausea and vomiting in elective surgery	Nabilone	Nabilone was not effective in reducing postoperative nausea and vomiting
Show	Epilepsy	Report from a Survey of Parents Regarding the Use of Cannabidiol (Medicinal cannabis) in Mexican Children with Refractory Epilepsy	Cannabis	CBD-rich cannabis reduced seizures in children with epilepsy according to a survey
Show		Cannabis as a substitute for prescription drugs – a cross-sectional study	Cannabis	Cannabis is used as a substitute for prescription drugs according to a large survey
Show	Posttraumatic stress disorder	Impact of Cannabis Use on Treatment Outcomes among Adults Receiving Cognitive-Behavioral Treatment for PTSD and Substance Use Disorders	Cannabis	Cannabis use had no relevant influence on outcome of behavioural therapies for co-occurring PTSD and substance use disorders
Show	Inflammation	Modulation of Human Peripheral Blood Mononuclear Cell Signaling by Medicinal Cannabinoids		Cannabis use alters immune cells in a way, which supports beneficial effects in inflammatory diseases and cancer
Show	Psychosis/ schizophrenia	Association between alcohol, cannabis, and other illicit substance abuse and risk of developing schizophrenia: a nationwide population based register study	Cannabis	Cannabis and alcohol use were associated with increased risk of schizophrenia
Show	Epilepsy; Rare diseases	Trial of Cannabidiol for Drug-Resistant Seizures in the Dravet Syndrome	Cannabidiol	Cannabidiol effective against epilepsy in Dravet syndrome
Show		Older adults' marijuana use, injuries, and emergency department visits	Cannabis	Cannabis use may increase injury risk among older adults
Show		Medical cannabis access, use, and substitution for prescription opioids and other substances: A survey of authorized medical cannabis patients	Cannabis	Patients prefer cannabis over opioids
Show		Cumulative Lifetime Marijuana Use and Incident Cardiovascular Disease in Middle Age: The Coronary Artery Risk Development in Young Adults (CARDIA) Study.	Cannabis	Cannabis use not associated with higher risk of cardiovascular diseases
Show	Tourette's syndrome	Preliminary Evidence on Cannabis Effectiveness and Tolerability for Adults With Tourette Syndrome	Cannabis	Cannabis effective in Tourette syndrome in case series
Show		Prolonged cannabis withdrawal in young adults with lifetime psychiatric illness.	Cannabis	Prolonged withdrawal symptoms in young cannabis users with psychiatric diseases
Show	Depression	Depression and anxiety among chronic pain patients receiving prescription opioids and medical marijuana	Cannabis	Depression is higher in pain patients receiving opioids compared to those receiving cannabis
Show		Childhood academic ability in relation to cigarette, alcohol and cannabis use from adolescence into early adulthood: Longitudinal Study of Young People in England (LSYPE).	Cannabis	High academic ability reduced the risk of tobacco smoking but increased the risk of cannabis use in adolescents
Show	HIV/AIDS	Marijuana Use Impacts Midlife Cardiovascular Events in HIV-Infected Men	Cannabis	Cannabis use may increase the risk for heart attacks in HIV positives
Show	Depression	Cannabis use and the course and outcome of major depressive disorder: A population based longitudinal study.	Cannabis	No association between cannabis use and depression
Show	Pain	Fatty Acid Amide Hydrolase Inhibitor Treatment in Men With Chronic Prostatitis/Chronic Pelvic Pain Syndrome: An Adaptive Double-blind, Randomized Controlled Trial.	Other cannabinoids	An inhibitor of FAAH did not influence pain in patients with chronic prostatitis
Show		Use of palmitoylethanolamide in carpal tunnel syndrome: a prospective randomized study	Other cannabinoids	Palmitoylethanolamide moderately effective in the treatment of carpal tunnel syndrome
Show		Individual prolactin reactivity modulates response of nucleus accumbens to erotic stimuli during acute cannabis intoxication: an fMRI pilot study	Cannabis	Cannabis increases the reaction to erotic stimuli
Show	Pain	Chronic pain patients' perspectives of medical cannabis	Cannabis	Medical cannabis patients rate cannabis as very effective
Show		Cannabis use patterns and motives: A comparison of younger, middle-aged, and older medical cannabis dispensary patients.	Cannabis	: Low age associated with higher problematic cannabis use among medical cannabis users
Show		Long lasting effects of chronic heavy cannabis abuse	Cannabis	Very heavy cannabis use may have long-lasting effects on the brain
Show		Medical Marijuana Laws May Be Associated With A Decline In The Number Of Prescriptions For Medicaid Enrollees	Cannabis	The medical use of cannabis may reduce medical costs of Medicaid in the USA by about one billion dollars
Show		Cannabis use is associated with reduced prevalence of non-alcoholic fatty liver disease: A cross-sectional study.	Cannabis	Cannabis use is associated with a lower prevalence of non-alcoholic fatty liver disease according to a large study
Show		Low-Dose Cannabidiol Is Safe but Not Effective in the Treatment for Crohn's Disease, a Randomized Controlled Trial.	Cannabidiol	Very low doses of CBD were not effective in Crohn’s disease
Show	Psychosis/ schizophrenia	The impact of current cannabis use on general cognitive function in people with psychotic illness	Cannabis	No difference in cognitive abilities between people with psychosis with and without cannabis use
Show		Is Cannabis Use Associated with Various Indices of Motivation Among Adolescents?	Cannabis
Show	Obsessive compulsive disorder	Refractory OCD Due to Thalamic Infarct With Response to Dronabinol	Delta-9-THC
Show	Pain	The MOBILE Study-A Phase IIa Enriched Enrollment Randomized Withdrawal Trial to Assess the Analgesic Efficacy and Safety of ASP8477, a Fatty Acid Amide Hydrolase Inhibitor, in Patients with Peripheral Neuropathic Pain.	Other cannabinoids	A FAAH inhibitor did not reduce neuropathic pain
Show	Dependency/ withdrawal	Intentional cannabis use to reduce crack cocaine use in a Canadian setting: A longitudinal analysis	Cannabis	Cannabis use reduced crack use
Show	Tourette's syndrome	Preliminary Evidence on Cannabis Effectiveness and Tolerability for Adults With Tourette Syndrome	Cannabis	Cannabis improved symptoms of Tourette syndrome
Show	Dependency/ withdrawal		Nabilone	Nabilone reduced cannabis use in cannabis-dependent persons
Show	Parkinson's disease	Medical Cannabis in Parkinson Disease: Real-Life Patients' Experience	Cannabis	Cannabis may be beneficial in Parkinson`s disease according to a survey
Show	Epilepsy	The use of cannabidiol for seizure management in patients with brain tumor-related epilepsy	Cannabidiol	CBD may be effective in epilepsy due to brain tumours according to a case series
Show	Multiple sclerosis; Pain	Dronabinol Is a Safe Long-Term Treatment Option for Neuropathic Pain Patients	Other cannabinoids	No significant difference between placebo and THC in the treatment of pain of patients with multiple sclerosis
Show	Appetite loss/weight loss	The Impact of Δ9-THC on the Psychological Symptoms of Anorexia Nervosa: A Pilot Study	Delta-9-THC	THC may improve symptoms of anorexia nervosa
Show	Pain	Medical Cannabis in Patients with Chronic Pain: Effect on Pain Relief, Pain Disability, and Psychological aspects. A Prospective Non randomized Single Arm Clinical Trial.	Cannabis	Cannabis tea effective in the treatment of chronic pain
Show	Pain; Parkinson's disease	Effect of medical cannabis on thermal quantitative measurements of pain in patients with Parkinson's disease.	Cannabis	Cannabis use improved pain and movement
Show	Epilepsy	Cannabidiol as a new treatment for drug-resistant epilepsy in tuberous sclerosis complex.	Cannabidiol	cannabidiol (CBD) was shown to be effective in the treatment of epilepsy due to Tuberous sclerosis complex
Show	Epilepsy	Cannabidiol as a Potential Treatment for Febrile Infection-Related Epilepsy Syndrome (FIRES) in the Acute and Chronic Phases.	Cannabidiol	Cannabidiol is effective in febrile infection-related epilepsy syndrome in a case series
Show	Parkinson's disease	Effect of medical cannabis on thermal quantitative measurements of pain in patients with Parkinson's disease.	Cannabis	Cannabis improves pain and movement in patients with Parkinson’s disease
Show	Pain	A preliminary evaluation of the relationship of cannabinoid blood concentrations with the analgesic response to vaporized cannabis.	Delta-9-THC	Moderate relationship between THC concentrations and reduction of pain
Show		Effects of tetrahydrocannabinol on balance and gait in patients with dementia: A randomised controlled crossover trial.	Delta-9-THC	No differences in the number and type of adverse events were found, and no falls occurred after administration of THC.
Show		Efficacy and Safety of Cannabidiol and Tetrahydrocannabivarin on Glycemic and Lipid Parameters in Patients With Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled, Parallel Group Pilot Study.	Other cannabinoids	THCV significantly decreased fasting plasma glucose and improved the function of cells in the pancreas
Show	Epilepsy	Marijuana use in adults admitted to a Canadian epilepsy monitoring unit.	Cannabis	Improvement in seizures, stress was decreased, sleep improved and memory/concentration was better
Show	Spasticity	Effective treatment of spasticity using dronabinol in pediatric palliative care.	Delta-9-THC	In the majority of pediatric palliative patients the treatment with dronabinol showed promising effects in treatment resistant spasticit.
Show		Subjective aggression during alcohol and cannabis intoxication before and after aggression exposure.	Cannabis	Subjective aggression significantly increased following aggression exposure in all groups while being sober.
Show	Pain;Spinal cord injury	An Exploratory Human Laboratory Experiment Evaluating Vaporized Cannabis in the Treatment of Neuropathic Pain From Spinal Cord Injury and Disease.	Cannabis	Inhaled cannabis reduces neuropathic pain in patients with spinal cord injury
Show	Bipolar disorders	Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood.	Cannabis	Cannabis showed beneficial effects in bipolar disorder
Show	Multiple sclerosis	The effect of cannabinoids on the stretch reflex in multiple sclerosis spasticity.	Cannabis	Cannabis reduces the stretch reflex in patients with multiple sclerosis
Show		Prior Cannabis Use Is Associated with Outcome after Intracerebral Hemorrhage.	Cannabis	Cannabinoids-positive patients had lower median disease scores on admission
Show	Pain	Dronabinol increases pain threshold in patients with functional chest pain: a pilot double-blind placebo-controlled trial.	Delta-9-THC	THC reduced pain intensity and odynophagia (painful swallowing, in the mouth or oesophagus).
Show	Epilepsy	CBD-enriched medical cannabis for intractable pediatric epilepsy: The current Israeli experience.	Cannabidiol	Improvement in behaviour and alertness, language, communication, motor skills and sleep
Show	Multiple sclerosis	Evaluating Sativex® in Neuropathic Pain Management: A Clinical and Neurophysiological Assessment in Multiple Sclerosis.	Other cannabinoids	Cannabis reduced neuropathic pain
Show	Alzheimer's disease	Safety and Efficacy of Medical Cannabis Oil for Behavioral and Psychological Symptoms of Dementia: An-Open Label, Add-On, Pilot Study.	Cannabis	Following aspects significantly decreased: Delusions, agitation/aggression, irritability, apathy, and sleep and caregiver distress
Show		Effects of Medical Marijuana on Migraine Headache Frequency in an Adult Population.	Other cannabinoids	Migraine headache frequency on average decreased from 10.4 to 4.6 headaches per month with the use of cannabis.
Show	Attention-deficit/hyperactivity disorder	Cannabinoids in attention-deficit/hyperactivity disorder: a randomised-controlled trial	Delta-9-THC;Cannabidiol	Cannabis may be helpful in the treatment of ADHD
Show	Bipolar disorders	Joint Effects: A Pilot Investigation of the Impact of Bipolar Disorder and Marijuana Use on Cognitive Function and Mood	Cannabis	Cannabis may be helpful in bipolar disorder
Show	Dependency/ withdrawal	Safety of oral dronabinol during opioid withdrawal in humans	Delta-9-THC	40 mg of THC caused increased heart rate and anxiety, which made dose-reduction necessary
Show	Epilepsy	Parental reporting of response to oral cannabis extracts for treatment of refractory epilepsy	Cannabis	About one third of children suffering from different forms of epilepsy experienced a more than 50 % reduction in seizures by the use of oral cannabis extracts.
Show	Pain	Efficacy of Inhaled Cannabis on Painful Diabetic Neuropathy	Cannabis	Inhaled cannabis demonstrated a dose dependent reduction in peripheral treatment-refractory neuropathic pain.
Show		Profiles of medicinal cannabis patients attending compassion centers in rhode island.	Cannabis	Most participants report that medicinal cannabis improves their pain symptomology.
Show		Neural Effects of Cannabinoid CB1 Neutral Antagonist Tetrahydrocannabivarin on Food Reward and Aversion in Healthy Volunteers.	Other cannabinoids	The natural cannabinoid tetrahydrocannabivarin (THCV) altered the nerve response to pleasant and unpleasant stimuli in a way that it “suggests therapeutic activity in obesity.
Show	Posttraumatic stress disorder	The efficacy of nabilone, a synthetic cannabinoid, in the treatment of PTSD-associated nightmares: A preliminary randomized, double-blind, placebo-controlled cross-over design study.	Nabilone	Nabilone reduced nightmares.
Show		Smoking and Diabetes Mellitus: Results from Meta-analysis with Eight Independent Replication Samples	Cannabis	Cannabis use was associated with a 30% reduction of diabetes risk
Show	Pain	Experience of adjunctive cannabis use for chronic non-cancer pain: Findings from the Pain and Opioids IN Treatment (POINT) study.	Cannabis	Pain patients, who receive opioids, experience better pain relief if they also take cannabis.
Show	HIV/AIDS	High-intensity cannabis use associated with lower plasma human immunodeficiency virus-1 RNA viral load among recently infected people who use injection drugs.	Cannabis	At least daily cannabis use was associated with significant lower plasma HIV viral loads.
Show	Cancer	Patterns of Use of Medical Cannabis Among Israeli Cancer Patients: A Single Institution Experience.	Cannabis	Cannabis use “is perceived as highly effective” by some patients with advanced cancer.
Show	Cancer;Nausea/vomiting	Dronabinol Treatment of Refractory Nausea and Vomiting Related to Peritoneal Carcinomatosis.	Delta-9-THC	THC may be very effective in the treatment of nausea and vomiting in end-stage cancer.
Show	Appetite loss/weight loss;Cancer; Nausea/vomiting;Pain	Improving Quality of Life With Nabilone During Radiotherapy Treatments for Head and Neck Cancers: A Randomized Double-Blind Placebo-Controlled Trial	Nabilone	Nabilone did not reduce pain and nausea in patients treated for head and neck cancer.
Show	Pain	Single dose delta-9-tetrahydrocannabinol in chronic pancreatitis patients: analgesic efficacy, pharmacokinetics and tolerability	Delta-9-THC	No effect of a single low dose of THC on abdominal pain resulting from chronic pancreatitis in clinical study.
Show	Dependency/ withdrawal;Pain	The prescription of medical cannabis by a transitional pain service to wean a patient with complex pain from opioid use following liver transplantation: a case report.	Cannabis	The use of cannabis reduced opioid consumption
Show	Alzheimer's disease	Tetrahydrocannabinol for neuropsychiatric symptoms in dementia: A randomized controlled trial.	Delta-9-THC	No reduction in NPS by low-dose THC (3×1.5mg), though it is well-tolerated
Show		Acute effects of delta-9-tetrahydrocannabinol, cannabidiol and their combination on facial emotion recognition: a randomised, double-blind, placebo-controlled study in cannabis users.	Cannabis;Delta-9-THC;Cannabidiol	Improvement of recognition of emotional facial affect by CBD and attenuation of the impairment induced by THC
Show		The effect of five day dosing with THCV on THC-induced cognitive, psychological and physiological effects in healthy male human volunteers: A placebo-controlled, double-blind, crossover pilot trial.	Delta-9-THC	Inhibition of some of the well-known effects of THC by THCV and potentiation of other effects
Show	Epilepsy	Cannabidiol in patients with treatment-resistant epilepsy: an open-label interventional trial.	Cannabidiol	Cannabidiol reduces seizure frequency in epilepsy of children and young adults
Show	Pain	The Pharmacokinetics, Efficacy, Safety, and Ease of Use of a Novel Portable Metered-Dose Cannabis Inhaler in Patients With Chronic Neuropathic Pain: A Phase 1a Study	Cannabis	A significant reduction in pain intensity was achieved after cannabis inhalation with a vaporizer.
Show	Dependency/ withdrawal	Nabiximols as an agonist replacement therapy during cannabis withdrawal: a randomized clinical trial	Cannabis	Sativex had no relevant long-term effect on cannabis dependence
Show	Pain	A double-blind, randomized, placebo-controlled, parallel group study of THC/CBD spray in peripheral neuropathic pain treatment	Cannabis	Significant improvements in pain, sleep quality and subjective evaluations of patients.
Show	Parkinson's disease	Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial	Cannabidiol	Significant improvement in well-being. No effects on motor functioning or neuroprotection.
Show		Endocannabinoids control platelet activation and limit aggregate formation under flow.	Other cannabinoids	Activation of cannabinoid receptors by cannabis use reduces platelet activation and blood clotting.
Show	Traumatic brain injury	Effect of marijuana use on outcomes in traumatic brain injury.	Cannabis	A positive THC screen is associated with decreased mortality in adult patients sustaining TBI [traumatic brain injury].
Show		Safety and pharmacokinetics of oral delta-9-tetrahydrocannabinol in healthy older subjects: A randomized controlled trial.	Delta-9-THC	THC appeared to be safe and well tolerated by healthy older individuals.
Show	Nausea/vomiting	Cannabis for intractable nausea after bilateral cerebellar stroke.	Cannabis	A woman with intractable nausea after cerebellar stroke responded well to a treatment with THC.
Show	Pain;Posttraumatic stress disorder; Sleep disorder	Use of a Synthetic Cannabinoid in a Correctional Population for Posttraumatic Stress Disorder-Related Insomnia and Nightmares, Chronic Pain, Harm Reduction, and Other Indications: A Retrospective Evaluation.	Nabilone	Nabilone caused significant improvements in insomnia, nightmares, chronic pain and other symptoms in patients suffering from posttraumatic stress disorder (PTSD).
Show	Multiple sclerosis	Long-term effectiveness and safety of nabiximols (tetrahydrocannabinol/cannabidiol oromucosal spray) in clinical practice.	Cannabis	Researchers found that “real-life data confirm the long-term effectiveness and tolerability of nabiximols [Sativex] for the treatment of resistant MSS [multiple sclerosis spasticity].
Show	Posttraumatic stress disorder	Preliminary, open-label, pilot study of add-on oral Δ9-tetrahydrocannabinol in chronic post-traumatic stress disorder.	Delta-9-THC	THC caused significant improvements in post-traumatic stress disorder (PTSD).
Show	Parkinson's disease	Cannabis (medical marijuana) treatment for motor and non-motor symptoms of Parkinson disease: an open-label observational study.	Cannabis	Analysis of specific motor symptoms revealed significant, also sleep and pain improvement after treatment with cannabis.
Show	Multiple sclerosis	Nabiximols (THC/CBD oromucosal spray, Sativex®) in clinical practice–results of a multicenter, non-interventional study (MOVE 2) in patients with multiple sclerosis spasticity.	Cannabis	The cannabis extract Sativex provided relief in 74.6% of participants.
Show	Posttraumatic stress disorder	Using cannabis to help you sleep: heightened frequency of medical cannabis use among those with PTSD.	Cannabis	Patients with high PTSD scores were more likely to use cannabis to improve sleep, and for coping reasons more generally.
Show	Sleep disorder	Impact of Dronabinol on Quantitative Electroencephalogram (qEEG) Measures of Sleep in Obstructive Sleep Apnea Syndrome.	Delta-9-THC	THC treatment yielded a shift in EEG (electroencephalogram) power toward delta and theta frequencies and a strengthening of normal rhythms in the sleep.
Show	Multiple sclerosis; Spasticity	Clinical experience with THC:CBD oromucosal spray in patients with multiple sclerosis-related spasticity.	Cannabis	The mean spasticity decreased by 57%.
Show	Multiple sclerosis; Spasticity	Clinical experiences with cannabinoids in spasticity management in multiple sclerosis.	Cannabis	The cannabis extract was effective in 80% of patients.
Show	Alzheimer's disease	Dronabinol for the treatment of agitation and aggressive behavior in acutely hospitalized severely demented patients with noncognitive behavioral symptoms.	Delta-9-THC	A treatment with oral THC was associated with significant decreases in agitation, as well as improvements in sleep duration and appetite.
Show	Epilepsy	Cannabis and other illicit drug use in epilepsy patients.	Cannabis	The use of cannabis did not affect disease severity in epilepsy.
Show	Pain	A double-blind, placebo-controlled, crossover pilot trial with extension using an oral mucosal cannabinoid extract for treatment of chemotherapy-induced neuropathic pain.	Cannabis	Reduction in pain intensity
Show	Pain	The subjective psychoactive effects of oral dronabinol studied in a randomized, controlled crossover clinical trial for pain.	Cannabis;Delta-9-THC	Oral THC had similar psychoactive effects to smoked marijuana
Show	Multiple sclerosis; Spasticity	Effect of dronabinol on progression in progressive multiple sclerosis (CUPID): a randomised, placebo-controlled trial.	Delta-9-THC	THC, which was given for 36 months, had no effect on progression compared to placebo
Show	Dependency/ withdrawal	Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment.	Cannabis	Objective ratings of opiate withdrawal decreased in patients using cannabis during stabilization
Show	Cancer chemotherapy; Pain	A Double-Blind, Placebo-Controlled, Crossover Pilot Trial With Extension Using an Oral Mucosal Cannabinoid Extract for Treatment of Chemotherapy-Induced Neuropathic Pain.	Cannabis	Five patients tended to respond to a treatment with cannabis
Show	Anxiety;Posttraumatic stress disorder	Cannabidiol enhances consolidation of explicit fear extinction in humans.	Cannabidiol	Cannabidiol enhances consolidation of fear extinction in humans.
Show	Dependency/ withdrawal	Cannabidiol for the treatment of cannabis withdrawal syndrome: a case report.	Cannabidiol	They were no major withdrawal symptoms.
Show	Dependency/ withdrawal	Cannabis as a substitute for alcohol and other drugs: A dispensary-based survey of substitution effect in Canadian medical cannabis patients.	Cannabis	Many patients substitute cannabis for alcohol, illegal and medicinal drugs
Show	Psychosis/ schizophrenia	A controlled family study of cannabis users with and without psychosis.	Cannabis	Cannabis does not cause psychosis by itself
Show	Pain	The Subjective Psychoactive Effects of Oral Dronabinol Studied in a Randomized, Controlled Crossover Clinical Trial For Pain.	Cannabis;Delta-9-THC	In pain patients, oral dronabinol has similar psychoactive effects to smoking cannabis.
Show	Cancer;Pain	An open-label extension study to investigate the long-term safety and tolerability of THC/CBD oromucosal spray and oromucosal THC spray in patients with terminal cancer-related pain refractory to strong opioid analgesics	Cannabis	The cannabis extract Sativex was generally well tolerated, with no evidence of a loss of effect for pain relief.
Show	Multiple sclerosis;Pain	A double-blind, randomized, placebo-controlled, parallel-group study of THC/CBD oromucosal spray in combination with the existing treatment regimen, in the relief of central neuropathic pain in patients with multiple sclerosis.	Cannabis	No significant difference between placebo and Sativex in Phase A; Phase B demonstrated an analgesic effect.
Show	Gastrointestinal disorder; Inflammation;Pain	Konikoff FM. Cannabis induces a clinical response in patients with Crohn's disease: a prospective placebo-controlled study	Cannabis	Cannabis produced significant clinical benefits in 10 of 11 patients with active Crohn’s disease.
Show	Pain	Low-dose vaporized cannabis significantly improves neuropathic pain	Cannabis	Cannabis reduced pain. No difference in efficacy between the two doses.
Show	Gastrointestinal disorder ;Inflammation	Marijuana Use Patterns Among Patients with Inflammatory Bowel Disease.	Cannabis	Patients find cannabis very helpful for symptom control.
Show	Sleep disorder	Around-the-clock oral THC effects on sleep in male chronic daily cannabis smokers.	Delta-9-THC	Higher THC concentrations were significantly associated with less difficulty falling asleep and more daytime sleep the following day.
Show	Cancer	The medical necessity for medicinal cannabis: prospective, observational study evaluating the treatment in cancer patients on supportive or palliative care.	Cannabis	In an open clinical study with cancer patients all symptoms improved significantly.
Show	HIV/AIDS	Marijuana smoking does not accelerate progression of liver disease in HIV-hepatitis C coinfection: a longitudinal cohort analysis.	Cannabis	The use of cannabis did not accelerate progression to significant liver fibrosis.
Show	Dependency/ withdrawal	Impact of cannabis use during stabilization on methadone maintenance treatment.	Cannabis	Symptoms of opiate withdrawal decrease in patients undergoing methadone maintenance treatment, who use cannabis.
Show	Multiple sclerosis	Treatment failure of intrathecal baclofen and supra-additive effect of nabiximols in multiple sclerosis-related spasticity: a case report.	Cannabis	A combination of baclofen injections into the cerebrospinal fluid and very low doses of the cannabis extract Sativex was highly effective.
Show	Pain	Comparison of the analgesic effects of dronabinol and smoked marijuana in daily marijuana smokers.	Cannabis;Delta-9-THC	THC (dronabinol) and smoked cannabis (marijuana) caused similar effects on pain sensitivity and pain tolerance.
Show	Dependency/ withdrawal	Nabilone decreases marijuana withdrawal and a laboratory measure of marijuana relapse.	Nabilone	The use of nabilone reduced withdrawal symptoms.
Show	Multiple sclerosis; Spasticity	A new multiple sclerosis spasticity treatment option: effect in everyday clinical practice and cost-effectiveness in Germany.	Cannabis	The cannabis extract sativex is effective in a large number of patients and well-tolerated in the long-term.
Show	Multiple sclerosis; Spasticity	Endocannabinoid system modulator use in everyday clinical practice in the UK and Spain.	Cannabis	Sativex appears to be a well-tolerated and useful add-on therapy in patients with spasticity due to multiple sclerosis.
Show	Spasticity	Proof of concept trial of dronabinol in obstructive sleep apnea.	Delta-9-THC	THC significantly improved this condition.
Show	Headache/migraine	Use of cannabis among 139 cluster headache sufferers.	Cannabis	Less than one third of self-reported users mention a relief of their attacks following inhalation.
Show	Dependency/ withdrawal	The dose effects of short-term dronabinol (oral THC) maintenance in daily cannabis users.	Delta-9-THC	THC dose-dependently attenuated cannabis withdrawal.
Show	HIV/AIDS	Marijuana smoking does not accelerate progression of liver disease in HIV-hepatitis C coinfection: a longitudinal cohort analysis	Cannabis	Cannabis does not increase the risk of liver fibrosis in patients co-infected with HIV and HCV
Show	Psychosis/ schizophrenia	Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia	Cannabidiol	CBD was as effective as amisulpride, a standard antipsychotic
Show	Multiple sclerosis; Pain;Spasticity	Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial.	Cannabis	Smoked cannabis was superior to placebo in reducing spasticity and pain.
Show		Acute effects of a single, oral dose of d9-tetrahydrocannabinol (THC) and cannabidiol (CBD) administration in healthy volunteers.	Delta-9-THC;Cannabidiol	CBD does not cause significant side effects
Show	Pain	Palmitoylethanolamide in the Treatment of Chronic Pain Caused by Different Etiopathogenesis.	Other cannabinoids	Significant pain relief with palmitoylethanolamide (PEA)
Show	Posttraumatic stress disorder	Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence.	Cannabis	Significant improvement in one patient with PSD with cannabis
Show	Pain	An efficient randomised, placebo-controlled clinical trial with the irreversible fatty acid amide hydrolase-1 inhibitor PF-04457845, which modulates endocannabinoids but fails to induce effective analgesia in patients with pain due to osteoarthritis of the knee.	Other cannabinoids	A FAAH inhibitor was not more effective than a placebo.
Show	Pain	Herbal cannabis use in patients labeled as fibromyalgia is associated with negative psychosocial parameters.	Cannabis	Many patients with fibromyalgia use cannabis products.
Show	Pain;Spasticity	Cannabis derivatives therapy for a seronegative stiff-person syndrome: a case report.	Cannabis	The cannabis extract was effective in a patient with stiff person syndrome.
Show	Traumatic brain injury	Early Survival of Comatose Patients after Severe Traumatic Brain Injury with the Dual Cannabinoid CB1/CB2 Receptor Agonist KN38-7271: A Randomized, Double-Blind, Placebo-Controlled Phase II Trial.	Other cannabinoids	Survival rates within 1 month of the injury were significantly better.
Show	Anxiety	Effects of delta-9-tetrahydrocannabinol on evaluation of emotional images.	Delta-9-THC	THC renders fearful faces less fearful
Show	Cancer;Pain	Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial.	Cannabis	Additional pain reduction following the two lower doses.
Show	Posttraumatic stress disorder	Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence.	Cannabis	Cannabis reduced course and intensity of symptoms.
Show	Anxiety;Posttraumatic stress disorder	Cannabinoid facilitation of fear extinction memory recall in humans.	Delta-9-THC	THC prevented the recovery of fear in this experiment of extinction learning.
Show	Multiple sclerosis; Pain;Spasticity	A questionnaire survey of patients and carers of patients prescribed Sativex as an unlicensed medicine.	Cannabis	Most respondents experienced improvements across a range of symptoms.
Show	Multiple sclerosis; Pain;Spasticity	Multiple Sclerosis and Extract of Cannabis: results of the MUSEC trial.	Cannabis	Significant improvement by the cannabis extract Cannador of spasticity and pain.
Show	Pain	Intractable neuropathic pain due to ulnar nerve entrapment treated with cannabis and ketamine 10%.	Cannabis	Significant pain improvement with cannabis and ketamine.
Show	Pain	Lack of effect of central nervous system-active doses of nabilone on capsaicin-induced pain and hyperalgesia.	Nabilone	The cannabinoid had no significant effect on acute experimental pain.
Show	Gastrointestinal disorder; Inflammation	Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study	Cannabis	Improvement in general health perception, social functioning, ability to work, physical pain and depression; weight gain; average rise in BMI; average Harvey-Bradshaw index was reduced
Show	Appetite loss/weight loss;HIV/AIDS	A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men	Cannabis	Cannabis administration was associated with significant increases in plasma levels of ghrelin and leptin, and decreases in PYY, but did not significantly influence insulin levels
Show	Diarrhoea; Gastrointestinal disorder	Randomized pharmacodynamic and pharmacogenetic trial of dronabinol effects on colon transit in irritable bowel syndrome-diarrhea	Delta-9-THC	THC had no significant effects on gut transit.
Show	Epilepsy	Seizure exacerbation in two patients with focal epilepsy following marijuana cessation.	Cannabis	Patients with epilepsy were able to control their seizures by the use of cannabis.
Show	Pain	A Randomized, Controlled Study to Investigate the Analgesic Efficacy of Single Doses of the Cannabinoid Receptor-2 Agonist GW842166, Ibuprofen or Placebo in Patients With Acute Pain Following Third Molar Tooth Extraction.	Other cannabinoids	No superior analgetic effect of the synthetic cannabinoid GW842166 over placebo.
Show	Obsessive compulsive disorder	Dronabinol, a cannabinoid agonist, reduces hair pulling in trichotillomania: a pilot study.	Delta-9-THC	Statistically significant reduction in symptom severity.
Show		Increased Blood Pressure Following Abrupt Cessation of Daily Cannabis Use.	Cannabis;Nabilone	In 6 of 13 subjects blood pressure increased significantly after cessation of cannabis use.
Show	Appetite loss/weight loss;Cancer;Nausea/ vomiting;Pain;Spasticity	[Cannabinoids in children] [Article in German] Cannabinoide bei Kindern.	Delta-9-THC	Reduced pain, spasticity and improved appetite and nausea
Show	Appetite loss/weight loss;Cancer	Delta-9-tetrahydrocannabinol may palliate altered chemosensory perception in cancer patients: results of a randomized, double-blind, placebo-controlled pilot trial.	Delta-9-THC	THC improved taste and appetite
Show		Subjective and Physiological Effects After Controlled Sativex and Oral THC Administration.	Cannabis;Delta-9-THC;Cannabidiol	Oral THC and the cannabis extract Sativex produced similar effects
Show	Anxiety	Cannabidiol Reduces the Anxiety Induced by Simulated Public Speaking in Treatment-Naïve Social Phobia Patients.	Cannabidiol	Cannabidiol significamtly reduced anxiety.
Show		Separate and combined effects of the cannabinoid agonists nabilone and Δ(9)-THC in humans discriminating Δ(9)-THC.	Delta-9-THC;Nabilone	THC caused similar effects as nabilone
Show	Anxiety	Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report.	Cannabidiol	CBD reduces anxiety in patients with generalized social anxiety disorder.
Show		The cannabinoid receptor agonist delta-9-tetrahydrocannabinol does not affect visceral sensitivity to rectal distension in healthy volunteers and IBS patients.	Delta-9-THC	THC did not modify visceral perception to rectal distension.
Show	Pain	Cannabis use in patients with fibromyalgia: effect on symptoms relief and health-related quality of life.	Cannabis	The use of cannabis was associated with reduction of some fibromyalgia symptoms.
Show		Cannabinoid effects on ventilation and breathlessness: A pilot study of efficacy and safety.	Cannabis	With cannabis participants felt less breathless
Show	Cancer	Spontaneous regression of septum pellucidum/forniceal pilocytic astrocytomas-possible role of Cannabis inhalation.	Cannabis	Spontaneous regression of benign brain tumour may have been associated with cannabis use.
Show	Multiple sclerosis; Spasticity	A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex(®) ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis.	Cannabis	The cannabis extract significantly reduced spasticity.
Show	Tourette's syndrome	Cannabinoids improve driving ability in a Tourette's patient.	Delta-9-THC	THC improved driving ability
Show	Gastrointestinal disorder;Inflammation	Cannabis use amongst patients with inflammatory bowel disease.	Cannabis	Cannabis use is frequent in patients with chronic intestinal inflammation
Show	Posttraumatic stress disorder	Medical cannabis use in post-traumatic stress disorder: a naturalistic observational study.	Cannabis	In most cases a significant improvement in quality of life and pain, with some positive changes in severity of posttraumatic stress disorder was observed.
Show		The medicinal use of cannabis and cannabinoids: an international survey on methods of intake.	Cannabis;Delta-9-THC;Nabilone	Preferred modes of use were smoking of cannabis (62.9 per cent), inhalation of cannabis with a vaporizer (23.6 per cent), oral use of cannabis in baked goods (7.9 per cent), oral use of cannabis as a tea (2.4 per cent), and oral use of dronabinol/Marinol (1.8 per cent).
Show	Diarrhoea; Gastrointestinal disorder;Inflammation	Treatment of Crohn's disease with cannabis: an observational study.	Cannabis	Of the 30 patients 21 improved significantly
Show	Diarrhoea; Gastrointestinal disorder	Pharmacogenetic Trial of a Cannabinoid Agonist Shows Reduced Fasting Colonic Motility in Patients with Non-Constipated Irritable Bowel Syndrome.	Delta-9-THC	Dronabinol reduces fasting motility of the colon in IBS patients with diarrhoea
Show	HIV/AIDS	A pilot study of the effects of cannabis on appetite hormones in HIV-infected adult men.	Cannabis	Cannabis modulates the concentration of appetite hormones
Show	Inflammation	Impact of cannabis treatment on the quality of life, weight and clinical disease activity in inflammatory bowel disease patients: a pilot prospective study.	Cannabis	Significant improvement of several symptoms.
Show	Pain	Cannabinoid-opioid interaction in chronic pain	Cannabis	Pain was significantly decreased
Show	Dependency/ withdrawal	Dronabinol for the treatment of cannabis dependence: a randomized, double-blind, placebo-controlled trial.	Delta-9-THC	THC caused significant improvement in treatment retention and withdrawal symptoms.
Show	Cancer	Marijuana use is not associated with cervical human papillomavirus natural history or cervical neoplasia in HIV-seropositive or HIV-seronegative women.	Cannabis	Cannabis use is not associated with cervical human papillomavirus natural history or cervical neoplasia in HIV-seropositive or HIV-seronegative women.
Show	Nausea/vomiting	Motion sickness, stress and the endocannabinoid system.		Volunteers who developed acute motion sickness (n = 7) showed lower endocannabinoid levels during parabolic flights.
Show	Spasticity	Tetrahydrocannabinol (THC) for cramps in amyotrophic lateral sclerosis: a randomised, double-blind crossover trial.	Delta-9-THC	There were no effects on cramp intensity, number of cramps and fasciculation intensity.
Show	Tourette's syndrome	Oral Delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: a case report.	Delta-9-THC	THC improved tics allowing parallel stimulant treatment of comorbid ADHD.
Show	Appetite loss/ weight loss	Cannabidiol attenuates the appetitive effects of Delta 9-tetrahydrocannabinol in humans smoking their chosen cannabis.	Cannabis	Effects depended on the ratio of CBD and THC with high CBD reducing appetite enhancing effects of THC.
Show	Spasticity; Spinal cord injury	A randomized, double-blinded, crossover pilot study assessing the effect of nabilone on spasticity in persons with spinal cord injury.	Nabilone	There was a significant decrease in spasticity by nabilone.
Show	Dystonia	Tardive Dystonia and the Use of Cannabis.	Cannabis;Delta-9-THC	Significant improvement by cannabis and dronabinol.
Show		Dramatic improvement of refractory Isaacs' syndrome after treatment with dronabinol.	Delta-9-THC	Dramathic improvement of symptoms (profuse sweating, muscular twitching, weight loss)
Show		The relationship between substance use and posttraumatic stress disorder in a methadone maintenance treatment program.	Cannabis	Cannabis may be used to self-treat posttraumatic stress disorder (PTSD)
Show		Improvement in refractory psychosis with dronabinol: four case reports.	Delta-9-THC	Significant improvement in four patients
Show	Pain	An Open-Label Comparison of Nabilone and Gabapentin as Adjuvant Therapy or Monotherapy in the Management of Neuropathic Pain in Patients with Peripheral Neuropathy.	Nabilone	The benefits of nabilone are similar as gabapentin
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting.	Cannabis	Cannabis was superior to placebo in reducing nausea and vomiting in patients refractory to other medications
Show	Pain	Effect of dronabinol on central neuropathic pain after spinal cord injury: a pilot study.	Delta-9-THC	No significant difference between THC and diphenhydramine.
Show	Multiple sclerosis	Randomized controlled trial of Sativex to treat detrusor overactivity in multiple sclerosis.	Cannabis	The cannabis extract had some effect on overactive bladder symptoms.
Show	Appetite loss/ weight loss;HIV/AIDS	Efficacy and tolerability of high-dose dronabinol maintenance in HIV-positive marijuana smokers: a controlled laboratory study.	Delta-9-THC	Tolerance developed to the appetite-increasing effects of THC.
Show	Pain	Smoked cannabis for chronic neuropathic pain: a randomized controlled trial.	Cannabis	Cannabis improved pain and sleep quality.
Show	Cancer;Pain	Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients With Intractable Cancer-Related Pain.	Cannabis;Delta-9-THC	A cannabis extract containing THC and CBD was superior in reducing pain than placebo.
Show	Bipolar disorders	Opposite relationships between cannabis use and neurocognitive functioning in bipolar disorder and schizophrenia.	Cannabis	In bipolar disorder subjects, cannabis use was associated with better neurocognitive function, but the opposite was the case for the schizophrenia subjects.
Show	Pain	Randomised Placebo Controlled Double Blind Clinical Trial of Cannabis Based Medicinal Product (Sativex) in Painful Diabetic Neuropathy: Depression is a Major Confounding Factor.	Cannabis	No difference between cannabis extract and placebo.
Show	Pain	The effects of nabilone on sleep in fibromyalgia: results of a randomized controlled trial.	Nabilone	Improvement of sleep by nabilone.
Show		PTSD contributes to teen and young adult cannabis use disorders.	Cannabis	People with PTSD have a higher risk for cannabis use
Show	Pain	Adjuvant topical therapy with a cannabinoid receptor agonist in facial postherpetic neuralgia.	Other cannabinoids	Five of eight patients experienced a good pain relief
Show	Multiple sclerosis; Spasticity	A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis	Cannabis	Significant reduction in treatment-resistant spasticity.
Show	HIV/AIDS;Pain	Smoked medicinal cannabis for neuropathic pain in HIV: a randomized, crossover clinical trial.	Cannabis	Significant pain relief with cannabis.
Show		Treatment of a hyperkinetic movement disorder during pregnancy with dronabinol.	Delta-9-THC	Improvement of her hyperkinetic movement disorder with no signs of tolerance
Show		Effect of Delta(9)-tetrahydrocannabinol, a cannabinoid receptor agonist, on the triggering of transient lower oesophageal sphincter relaxations in dogs and humans.	Delta-9-THC	THC reduced acid reflux episodes in the first hour after a meal.
Show	Multiple sclerosis	Psychopathological and cognitive effects of therapeutic cannabinoids in multiple sclerosis: a double-blind, placebo controlled, crossover study.	Cannabis	Cannabis did not impair cognition
Show	Nausea/vomiting; HIV/AIDS; Pain;Depression; Anxiety	Marijuana Effectiveness as an HIV Self-Care Strategy.	Cannabis	Participants rated cannabis as similar effective as other medications for the treatment of their symptoms.
Show		Relief oriented use of marijuana by teens.	Cannabis	20 participants said that they used cannabis to treat health problems.
Show		Intestinal Lymphatic Transport Enhances the Post-Prandial Oral Bioavailability of a Novel Cannabinoid Receptor Agonist Via Avoidance of First-Pass Metabolism.	Other cannabinoids	Systemic bioavailability of the cannabinoid CRA13 increased by more than 4-fold if taken together with a fat-rich meal.
Show	Headache/migraine	Cluster attacks responsive to recreational cannabis and dronabinol.	Cannabis;Delta-9-THC	Cannabis and THC aborted attacks of headaches.
Show	Dependency/ withdrawal	Intermittent marijuana use is associated with improved retention in naltrexone treatment for opiate-dependence.	Cannabis	Better adherence to natrexone therapy with intermittend cannabis use
Show		Synthetic delta-9-tetrahydrocannabinol (dronabinol) can improve the symptoms of schizophrenia.	Cannabis	Improvement in 4 of 6 participants, of whom 3 showed a significant improvement.
Show	Spasticity; Multiple sclerosis	Lack of effect of cannabis-based treatment on clinical and laboratory measures in multiple sclerosis.	Cannabis	There was no effect of the cannabis extract on spasticity
Show	Spasticity;Pain	Reposition of a dislocated shoulder under use of cannabis.	Cannabis	Pain and muscular tone decreased and the shoulder was relocated easily.
Show	Dependency/ withdrawal	White matter integrity in adolescents with histories of marijuana use and binge drinking.	Cannabis	Brain damage was less in alcohol users who used also cannabis than in alcohol only users.
Show	Dependency/ withdrawal	Cannabis as a substitute for alcohol and other drugs	Cannabis	40 % use cannabis to substitute for alcohol, 26 % to substitute for illegal drugs
Show	Pain	Characteristics of patients with chronic pain accessing treatment with medical cannabis in Washington State.	Cannabis	88 % suffer from more than one pain syndrome
Show	Cancer	A population-based case-control study of marijuana use and head and neck squamous cell carcinoma.	Cannabis	Subjects who used cannabis had a reduced cancer risk.
Show	Multiple sclerosis; Pain	Cannabinoid-induced effects on the nociceptive system: a neurophysiological study in patients with secondary progressive multiple sclerosis.	Cannabis	The study provides objective neurophysiological evidence that cannabinoids modulate the nociceptive system.
Show	Nausea/vomiting	Use of medical marijuana for treatment of severe intractable nausea after laparoscopic Roux-en-Y gastric bypass surgery: case report.	Delta-9-THC	THC relieved nausea refractory to other medications
Show	Pain	Comparison of analgesic effects and patient tolerability of nabilone and dihydrocodeine for chronic neuropathic pain: randomised, crossover, double blind study.	Nabilone	Nabilone as effective as hydrocodeine in treating neuropatic pain
Show	Nausea/vomiting; Appetite loss/ weight loss	Evaluation of oral cannabinoid-containing medications for the management of interferon and ribavirin-induced anorexia, nausea and weight loss in patients treated for chronic hepatitis C virus.	Delta-9-THC;Nabilone	Improvement of appetite and reduction of nausea and vomiting by nabilone and dronabinol (THC)
Show	Appetite loss/ weight loss; Cancer;Pain	Adjunctive nabilone in cancer pain and symptom management: a prospective observational study using propensity scoring.	Nabilone	Significant improvement of pain
Show	Pain	A Randomized, Placebo-Controlled, Crossover Trial of Cannabis Cigarettes in Neuropathic Pain.	Cannabis	Significant improvement of pain
Show		Improvement in refractory obsessive compulsive disorder with dronabinol.	Delta-9-THC	Significant symptom improvement
Show	Multiple sclerosis; Dystonia	Current status of cannabis treatment of multiple sclerosis with an illustrative case presentation of a patient with MS, complex vocal tics, paroxysmal dystonia, and marijuana dependence treated with dronabinol.	Delta-9-THC	Significant improvement of symptoms
Show	Pain	Lack of analgesia by oral standardized cannabis extract on acute inflammatory pain and hyperalgesia in volunteers.	Cannabis	The cannabis extract showed no analgesic effect in acute experimental pain
Show	Pain	Analgesic and antihyperalgesic effects of nabilone on experimental heat pain.	Nabilone	Nabilone did not reduce experimental heat pain
Show	Alzheimer's disease	The cannabinoid receptor agonist nabilone for the treatment of dementia-related agitation.	Nabilone	Dramatic reduction in the severity of agitation and other behavioural symptoms
Show	Dependency/ withdrawal	Use of dronabinol for cannabis dependence: two case reports and review.	Delta-9-THC	THC reduced withdrawal symptoms in cannabis dependence
Show	Pain	Nabilone for the treatment of pain in fibromyalgia.	Nabilone	Nabilone improved symptoms and was well-tolerated
Show	Pain	Efficacy of dronabinol as an adjuvant treatment for chronic pain patients on opioid therapy.	Delta-9-THC	THC reduced pain
Show	Cancer	Nabilone for the treatment of paraneoplastic night sweats: a report of four cases.	Nabilone	Significant improvement of night sweats within 2 days
Show	Pain	A prospective identification of neuropathic pain in specific chronic polyneuropathy syndromes and response to pharmacological therapy.	Cannabis;Nabilone	Similar treatment effects and side effects of cannabinoids compared to other medications
Show	Pain	Open-label, add-on study of tetrahydrocannabinol for chronic nonmalignant pain.	Delta-9-THC	5 patients reported adequate response to the treatment.
Show	Epilepsy	Marijuana: an effective antiepileptic treatment in partial epilepsy? A case report and review of the literature.	Cannabis	Significant improvement of epilepsy with the use of cannabis.
Show	Pain	Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers.	Cannabis	A medium dose of cannabis reduced pain, while a high dose increased pain induced by capsaicin
Show	Multiple sclerosis; Pain	Oromucosal ∆9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial.	Cannabis	No development of tolerance within a period of two years of treatment
Show		[Fitness to drive in spite (because) of THC] [Article in German]	Cannabis	Significant improvement of driving-related performance
Show	Pain	Sativex successfully treats neuropathic pain characterised by allodynia: A randomised, double-blind, placebo-controlled clinical trial.	Cannabis	Significant improvement in pain by cannabis
Show		Vaporization as a smokeless cannabis delivery system: a pilot study.	Cannabis	Vaporization of cannabis is a safe and effective mode of delivery of THC
Show	Appetite loss/ weight loss	Anorexia of aging in long term care: is dronabinol an effective appetite stimulant? – a pilot study.	Delta-9-THC	A trend towards weight gain
Show	Nausea/vomiting; Appetite loss/ weight loss;HIV/AIDS	THC improves appetite and reverses weight loss in AIDS patients	Delta-9-THC	THC improved appetite and weight and reduced nausea
Show	Appetite loss/weight loss;HIV/AIDS	Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.	Cannabis;Delta-9-THC	THC and cannabis caused an increase in caloric intake and weight
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone for delayed chemotherapy-induced nausea and vomiting.	Delta-9-THC	Dronabinol was as effective as ondansetron in reducing nausea and vomiting. Combination therapy was not more effective.
Show	Spasticity; Multiple sclerosis	Randomized controlled trial of cannabis-based medicine in spasticity caused by multiple sclerosis	Cannabis	Significantly reduction in spasticity
Show	HIV/AIDS;Pain	Cannabis in painful HIV-associated sensory neuropathy: A randomized placebo-controlled trial.	Cannabis	Smoked cannabis was well tolerated and effectively relieved chronic neuropathic pain from HIV-associated sensory neuropathy.
Show	Glaucoma	Dronabinol and retinal hemodynamics in humans.	Delta-9-THC	THC reduced intraoculat pressure and improved blood circulation in the retina.
Show	Pain	Nabilone for the treatment of pain in fibromyalgia.	Nabilone	Significant reduction of pain and improvement of quality of life with nabilone
Show	Pain	Efficacy of dronabinol as an adjuvant treatment for chronic pain patients on opioid therapy	Delta-9-THC	THC had an additional effect on pain relief
Show	Spasticity;Spinal cord injury;Pain	Sativex® in the Treatment of Central Neuropathic Pain due to Spinal Cord Injury: A Randomised Controlled Study	Cannabis	primary outcome mean NRS 11 poitn pain scale – nod difference – BPI secondary ourcome benefit – significant at p<0.032
Show		Effects of a cannabinoid receptor agonist on colonic motor and sensory functions in humans: a randomized, placebo-controlled study.	Delta-9-THC	THC relaxes the colon and reduces postprandial colonic motility
Show	Cancer;Cancer chemotherapy	Medicinal cannabis does not influence the clinical pharmacokinetics of irinotecan and docetaxel.	Cannabis	Cannabis did not influence the pharmacokinetics of the two anti-cancer drugs
Show	Bipolar disorders	The effect of extreme marijuana use on the long-term course of bipolar I illness: a single case study.	Cannabis	Cannabis decreased the number of depressed days and increased the number of hypomanic days.
Show	Multiple sclerosis	Cannabis; adverse effects from an oromucosal spray.	Cannabis	The spray caused reversible damage to the mucosa
Show		Long term marijuana users seeking medical cannabis in California (2001-2007): demographics, social characteristics, patterns of cannabis and other drug use of 4117 applicants.	Cannabis
Show	Spasticity; Spinal cord injury	The treatment of spasticity with Delta(9)-tetrahydrocannabinol in persons with spinal cord injury.	Delta-9-THC	Significant improvement of spasticity with THC
Show	Multiple sclerosis	Randomised controlled study of cannabis-based medicine (Sativex®) in patients suffering from multiple sclerosis associated detrusor overactivity	Cannabis	A significant reduction in the number of voids per day and during the night.
Show	Spasticity; Multiple sclerosis	A randomised controlled study of Sativex® in patients with symptoms of spasticity due to multiple sclerosis	Cannabis	Spasticity of patients who received cannabis and complied with the study protocol was significantly reduced compared to placebo.
Show	Nausea/vomiting; Appetite loss/weight loss;Cancer;Pain; Depression;Anxiety	The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients	Nabilone	Nabilone treatment improved pain, nausea, appetite and several other symptoms
Show	Pain	Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine.	Delta-9-THC	There was a synergistic effect between THC and morphine on the affective component of pain but not on the sensory component
Show	Pain	[(9)-tetrahydrocannabinol and the opioid receptor agonist piritramide do not act synergistically in postoperative pain.] [Article in German]	Delta-9-THC	Application of THC reduced the need of an opioid to treat postoperative pain but the difference to placebo was not significant
Show	Nausea/vomiting ;Appetite loss/weight loss;Cancer;Cancer chemotherapy	[Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.] [Article in German]	Delta-9-THC	A significant increase in appetite and decrease in nausea in most patients.
Show		Dronabinol reduces signs and symptoms of idiopathic intracranial hypertension: a case report.	Cannabis;Delta-9-THC	Improvement of signs and symptoms of the disease
Show		Cannabidiol monotherapy for treatment-resistant schizophrenia	Cannabidiol	CBD monotherapy was not effective in treatment-resistant schizophrenia
Show	Alzheimer's disease	Delta-9-tetrahydrocannabinol for night-time agitation in severe dementia	Delta-9-THC	Reduction in night-time agitation in actigraphy and in the neuropsychiatric inventory NPI
Show	Pain	A multicenter dose-escalation study of the analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain management.	Cannabis	The optimal dose was 10 mg Cannador, effectively reducing postoperative pain without serious side effects.
Show	Multiple sclerosis	The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS).	Cannabis;Delta-9-THC	Cannabis and dronabinol caused a significant reduction in incontinence
Show	Spasticity; Spinal cord injury	[Respiratory failure due to delta-9-tetrahydrocannabinol in a tetraplegic patient.]. [Article in German]	Delta-9-THC	Dronabinol reduced spasticity but worsened respiration
Show	Cancer	A pilot clinical study of Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme.	Delta-9-THC	THC was well tolerated in this pilot study of intrakranial cannabinoid administration
Show	Pain	Delta-9-THC based monotherapy in fibromyalgia patients on experimentally induced pain, axon reflex flare, and pain relief.	Delta-9-THC	Five of the nine patients withdrew from the study due to side effects. Four patients experienced significant pain relief
Show	Appetite loss/ weight loss;Cancer	Comparison of orally administered cannabis extract and delta-9-tetrahydrocannabinol in treating patients with cancer-related anorexia-cachexia syndrome: a multicenter, phase III, randomized, double-blind, placebo-controlled clinical trial from the Cannabis-in-Cachexia-Study-Group	Cannabis;Delta-9-THC	No difference between cannabis, THC and placebo
Show		[Topical cannabinoid agonists : An effective new possibility for treating chronic pruritus.] [Article in German]	Other cannabinoids	Topical application of a cream with N-palmitoyl ethanolamine had a good antipruritic effect in most patients.
Show	Pain	[Benefits of an add-on treatment with the synthetic cannabinomimetic nabilone on patients with chronic pain – a randomized controlled trial.] [Article in German]	Nabilone	Nabilone caused a significant reduction in pain and improvement of quality of life.
Show	Pain	Effects of nabilone, a synthetic cannabinoid, on postoperative pain.	Nabilone	No pain reduction with nabilone.
Show	Multiple sclerosis; Pain	Low dose treatment with the synthetic cannabinoid Nabilone significantly reduces spasticity-related pain : A double-blind placebo-controlled cross-over trial.	Nabilone	Significant reduction of pain
Show	Glaucoma	Effect of Sublingual Application of Cannabinoids on Intraocular Pressure: A Pilot Study.	Delta-9-THC;Cannabidiol	Significant reduction of intraocular pressure
Show	Nausea/vomiting; Cancer chemotherapy;Pain	Cannabinoids in the management of intractable chemotherapy-induced nausea and vomiting and cancer-related pain.	Nabilone	Significant improvement in one case of intractable neuropathic pain and one case of refractory cinv
Show	Pain	Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis.	Cannabis	Cannabis produced improvements in pain and sleep
Show		Efficacy and safety of dexanabinol in severe traumatic brain injury: results of a phase III randomised, placebo-controlled, clinical trial.	Other cannabinoids	No effect of dexanabinol
Show	Nausea/vomiting	Survey of medicinal cannabis use among childbearing women: patterns of its use in pregnancy and retroactive self-assessment of its efficacy against 'morning sickness'.	Cannabis	Cannabis effective against nausea and vomiting
Show	Pain	Experience with the synthetic cannabinoid nabilone in chronic noncancer pain.	Nabilone	9 patients reported reduced pain intensity
Show	Nausea/vomiting	Prevention of nausea and vomiting following breast surgery.	Delta-9-THC	Postoperative nausea and vomiting was reduced by prophylactic administration of dronabinol and prochlorperazine
Show		Effect of a cannabinoid agonist on gastrointestinal transit and postprandial satiation in healthy human subjects: a randomized, placebo-controlled study.	Delta-9-THC	THC retarded gastric emptying
Show	Nausea/vomiting	Cannabis use improves retention and virological outcomes in patients treated for hepatitis C.	Cannabis	Participants who used cannabis maintained adherence to treatment more offen
Show	Spasticity;Multiple sclerosis;Pain	Long-term use of a cannabis-based medicine in the treatment of spasticity and other symptoms in multiple sclerosis.	Cannabis	Long-term use of cannabis maintains its therapeutic effects
Show	Spasticity;Multiple sclerosis;Pain	Cannabis use in patients with multiple sclerosis.	Cannabis	A subgroup of patients with severe disabilitiy appears to derive some benefit
Show	Pain	Evaluation of herbal cannabis characteristics by medical users: a randomized trial.	Cannabis	Medical cannabis users can appreciate differences in herbal cannabis products
Show	Dependency/ withdrawal	Concurrent cannabis use during treatment for comorbid ADHD and cocaine dependence: effects on outcome.	Cannabis	Moderate cannabis use had a positive effect of retention rates and abstinence from cocaine
Show	Spasticity; Multiple sclerosis	Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up.	Cannabis;Delta-9-THC	Spasticity in the Ashworth scale was significantly reduced by an average of 1.82 in the THC group; no significant reduction in the cannabis group
Show	Spasticity; Multiple sclerosis	Cannabis-based medicinal extract (Sativex) produced significant improvements in a subjective measure of spasticity which were maintained on long-term treatment with no evidence of tolerance.	Cannabis	Beneficial effects of cannabis on spasticity in MS seem to be maintained over long-term treatment, with no evidence of tolerance.
Show	HIV/AIDS;Pain	Smoked cannabis therapy for HIV-related painful peripheral neuropathy: results of a randomized, placebo-controlled clinical trial.	Cannabis	Smoked cannabis is effective in reducing HIV-related neuropathic pain
Show	Epilepsy	Treatment with CBD in oily solution of drug-resistant paediatric epilepsies.	Cannabidiol	Improvement of epilepsy without side effects
Show	Pain	Standardized cannabis extract in the treatment of postherpetic neuralgia – a randomized, double-blind, placebo-controlled cross-over study.	Cannabis	Cannabis did not reduce pain
Show	Multiple sclerosis;Pain	Randomized, controlled trial of cannabis-based medicine in central pain in multiple sclerosis.	Cannabis	Cannabis is effective in reducing pain and sleep disturbance in patients with multiple sclerosis related central neuropathic pain
Show	Nausea/vomiting; HIV/AIDS	Marijuana use and its association with adherence to antiretroviral therapy among HIV-infected persons with moderate to severe nausea.	Cannabis	Cannabis improved adherence to antiretroviral therapy in HIV/AIDS
Show	Appetite loss/weight loss; HIV/AIDS; Alzheimer's disease	Dronabinol and marijuana in HIV(+) marijuana smokers: acute effects on caloric intake and mood.	Cannabis;Delta-9-THC	THC and cannabis cause increased caloric intake
Show	Appetite loss/weight loss	Dronabinol – eine mögliche neue Therapieoption bei COPD-Patienten mit pulmonaler Kachexie [Dronabinol, a possible new therapeutic option in patients with COPD and pulmonal cachexia]	Delta-9-THC	On average 1,5 kg of weight gain and increase of walking distance
Show	Nausea/vomiting; Appetite loss/weight loss;HIV/AIDS; Pain;Anxiety	Cannabis use in HIV for pain and other medical symptoms.	Cannabis	27% used cannabis for the treatment of various symptoms
Show		Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction.	Delta-9-THC	THC is associated with transient exacerbation in core psychotic and cognitive deficits in schizophrenia.
Show	Pain;Depression ;Anxiety	Cannabis use in sickle cell disease: a questionnaire study.	Cannabis	36% had used cannabis to treat symptoms
Show	Dependency/ withdrawal	Low efficacy of non-opioid drugs in opioid withdrawal symptoms.	Cannabis	Only low efficacy of cannabis in alleviating opioid withdrawal symptoms
Show		Efficacy and tolerance of the cream containing structured physiological lipids with endocannabinoids in the treatment of uremic pruritus: a preliminary study.	Other cannabinoids	Improvement of pruritus with the cream
Show		The medicinal use of cannabis in the UK: results of a nationwide survey.	Cannabis	Cannabis use was reported by 25 % of patients with chronic pain and 22 % of patients with multiple sclerosis
Show		Clinical improvement and reduction of immunosuppressive drug therapy in cannabis treated patients with crohn's disease.	Cannabis	The majority of patients found a substantial improvement of their symptoms
Show	Multiple sclerosis	Cannabinoid influence on cytokine profile in multiple sclerosis.	Cannabis;Delta-9-THC	There were no significant effects of cannabinoids on the cytokine profiles examined.
Show	Pain	Efficacy of two cannabis based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial.	Cannabis;Delta-9-THC	Significant pain relief and improvement of sleep
Show	Parkinson's disease	Cannabis for dyskinesia in Parkinson disease: a randomized double-blind crossover study.	Cannabis	Cannabis had no treatment effect on levodopa-induced dyskinesia.
Show	Parkinson's disease	Survey on cannabis use in Parkinson's disease: subjective improvement of motor symptoms.	Cannabis	25% of the respondents had taken cannabis and 45.9% of these described some form of benefit.
Show	Multiple sclerosis; Pain	Does the cannabinoid dronabinol reduce central pain in multiple sclerosis? Randomised double blind placebo controlled crossover trial	Delta-9-THC	Significant reduction of pain by THC
Show	Spasticity;Multiple sclerosis;Pain;Tremor	Do cannabis-based medicinal extracts have general or specific effects on symptoms in multiple sclerosis? A double-blind, randomized, placebo-controlled study on 160 patients.	Cannabis	Spasticity scores were significantly reduced by cannabis.
Show	Spasticity; Multiple sclerosis	Efficacy of tetrahydrocannabinol in patients refractory to standard antiemetic therapy.Efficacy, safety and tolerability of an orally administered cannabis extract in the treatment of spasticity in patients with multiple sclerosis: a randomized, double-blind, placebo-controlled, crossover study.	Cannabis	Significant reduction in spasm frequency in the 37 patients who received at least 90% of the dose.
Show	Multiple sclerosis	An open-label pilot study of cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis.	Cannabis	Urinary urgency, the number and volume of incontinence episodes, frequency and nocturia all decreased.
Show	Multiple sclerosis; Tremor	The effect of cannabis on tremor in patients with multiple sclerosis.	Cannabis;Delta-9-THC;Other cannabinoids	No significant improvement of tremor
Show	Pain	Are oral cannabinoids safe and effective in refractory neuropathic pain?	Delta-9-THC	No significant decraese of pain in 7 patients, more than 60% decrease in one patient
Show	Dependency/ withdrawal	Marijuana withdrawal in humans: effects of oral THC or divalproex.	Delta-9-THC	THC abolished withdrawal symptoms
Show	Appetite loss/weigh t loss;HIV/AIDS ;Pain;Depression	Patterns of marijuana use among patients with HIV/AIDS followed in a public health care setting.	Cannabis	Improvement of pain, appetite and depression/anxiety by using cannabis
Show	Appetite loss/weight loss;Spasticity; Pain;Depression	Survey of cannabis use in patients with amyotrophic lateral sclerosis.	Cannabis	Moderate improvement of pain, spasticity, appetite and depression
Show	Pain	Initial experiences with medicinal extracts of cannabis for chronic pain: results from 34 'N of 1' studies.	Cannabis	Improvement of pain
Show		Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults.	Cannabis;Delta-9-THC;Cannabidiol	THC had sedative effects, CBD had alerting effects
Show		Cannabis improves night vision: A pilot study of dark adaptometry and scotopic sensitivity in kif smokers of the Rif Mountains of Northern Morocco.	Cannabis;Delta-9-THC	Oral THC and smoking of cannabis improved night vision
Show	Dependency/ withdrawal	Cannabis as a Substitute for Alcohol: A Harm-Reduction Approach	Cannabis;Nabilone	Cannabis is a successful substituent of alcohol
Show	Spasticity;Spinal cord injury;Multiple sclerosis;Pain	A preliminary controlled study to determine whether whole-plant cannabis extracts can improve intractable neurogenic symptoms.	Cannabis;Delta-9-THC;Cannabidiol	Pain relief associated with both THC and CBD was significantly superior to placebo. Impaired bladder control, muscle spasms and spasticity were improved by cannabis in some patients
Show	Appetite loss/ weight loss; Alzheimer's disease	Safety and efficacy of dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia: A retrospective chart review	Delta-9-THC	Weight gain in all, reduction of agitation in 65%.
Show	HIV/AIDS	Short-term effects of cannabinoids in patients with HIV-1 infection: a randomized, placebo-controlled clinical trial.	Cannabis;Delta-9-THC	Cannabis and THC had no significant effect on HI virus load and on CD4+ and CD8+ cell count
Show	Spasticity;Spinal cord injury	The treatment of spasticity with D9-tetrahydrocannabinol (D9-THC) in patients with spinal cord injury	Delta-9-THC	Significant reduction of spasticity
Show	Spasticity;Dystonia; Epilepsy;Anxiety	Experiences with THC-treatment in children and adolescents	Delta-9-THC	Positive effects of THC in children with severe neurological disorders
Show	Multiple sclerosis;Pain	Randomised controlled trial of cannabis based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis.	Cannabis	Significant reduction in pain
Show	Pain	Efficacy of two cannabis-based medicinal extracts for relief of central neuropathic pain from brachial plexus avulsion: results of a randomised controlled trial	Cannabis;Delta-9-THC	Significant pain relief and improvement of sleep
Show	Pain	Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain: a randomized controlled trial.	Other cannabinoids	Significant reduction of pain
Show	Pain	Cannabis use for chronic non-cancer pain: results of a prospective survey.	Cannabis	Cannabis use is prevalent among the chronic non-cancer pain population
Show	Alzheimer's disease	Open-label study of dronabinol in the treatment of refractory agitation in Alzheimer’s disease: a pilot study	Delta-9-THC	Significant reduction of agitation
Show	HIV/AIDS;Pain	The effects of smoked cannabis in painful peripheral neuropathy and cancer pain refractory to opiods.	Cannabis	10 of the 16 participants experienced a greater than 30% reduction in their pain
Show	Tourette's syndrome	Delta 9-tetrahydrocannabinol (THC) is effective in the treatment of tics in Tourette syndrome: a 6-week randomized trial.	Delta-9-THC	Results provide evidence that THC is effective in the treatment of tics.
Show	Pain	Lack of analgesic efficacy of oral delta-9-tetrahydrocannabinol in postoperative pain.	Delta-9-THC	5 mg was ineffective in reduding postoperative pain.
Show	Spasticity;Multiple sclerosis;Pain	Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial.	Cannabis;Delta-9-THC	No effect of cannabinoids on spasticity as measured by the Ashworth scale, while patient-reported spasticity and pain decreased.
Show	Pain	A case of cannabinoid rotation in a young woman with chronic cystitis	Delta-9-THC;Nabilone	THC reduced pain with low side effects; nabilone caused strong psychic side effects
Show	Pain	Cannabis reduces opioid dose in the treatment of chronic non-cancer pain.	Cannabis	Improvement in pain, spasticity, bladder spasm, and sleep.
Show	Spasticity; Multiple sclerosis; Pain;Depression	Cannabis use as described by people with multiple sclerosis.	Cannabis	Improvement of pain, spasticity and anxiety/depression
Show	Pain	The analgesic effect of oral delta-9-tetrahydrocannabinol (THC), morphine, and a THC-morphine combination in healthy subjects under experimental pain conditions.	Delta-9-THC	No effect of THC on experimental pain in healthy subjects
Show		Survey on the medical use of cannabis and THC in Germany.	Cannabis;Delta-9-THC	Cannabis and THC were effective in many conditions
Show		Histamine induced responses are attenuated by a cannabinoid receptor agonist in human skin.	Other cannabinoids	Peripheral administration of HU210 attenuates histamine-induced itch
Show	Pain	Cannabinoid agonists attenuate capsaicin-induced responses in human skin.	Other cannabinoids	A topically applied cannabinoid receptor agonist (HU210) reduced pain caused by capsaicin
Show	Appetite loss/weight loss;Cancer	Dronabinol versus megestrol acetate versus combination therapy for cancer-associated anorexia: a North Central Cancer Treatment Group study.	Delta-9-THC	megestrol acetate was superior to THC
Show	Pain	[The therapeutic use of delta-9-tetrahydrocannabinol (dronabinol) in refractory neuropathic pain] [Article in French].	Delta-9-THC	No signficant effect of THC on pain
Show	Tourette's syndrome	Treatment of Tourette's syndrome with Delta 9-tetrahydrocannabinol (THC): a randomized crossover trial.	Delta-9-THC	Significant improvement of tics and obsessive-compulsive behavior after treatment with THC.
Show	Dystonia	Randomised, double-blind, placebo-controlled trial to assess the potential of cannabinoid receptor stimulation in the treatment of dystonia.	Nabilone	No significant reduction in dystonia following treatment with nabilone
Show	Spasticity; Multiple sclerosis	Safety, tolerability, and efficacy of orally administered cannabinoids in MS.	Cannabis;Delta-9-THC	Compared with placebo, neither THC nor plant-extract treatment reduced spasticity.
Show		Preliminary observation with dronabinol in patients with intractable pruritus secondary to cholestatic liver disease.	Delta-9-THC	THC signficantly reduced intractable cholestatic related pruritus
Show	Spasticity	A casuistic rationale for the treatment of spastic and myocloni in a childhood neurodegenerative disease: neuronal ceroid lipofuscinosis of the type Jansky-Bielschowsky.	Delta-9-THC	Improvement of spasticity
Show		Chronic Cannabis Use in the Compassionate Investigational New Drug Program: An Examination of Benefits and Adverse Effects of Legal Clinical Cannabis	Cannabis	Effective treatment of different serious conditions with cannabis
Show	Dependency/ withdrawal	Crack heads and roots daughters: The therapeutic use of cannabis in Jamaica.	Cannabis	Cannabis was the most effective and readily available therapy to quit cocaine use
Show	Nausea/vomiting	Hyperemesis Gravidarum and Clinical Cannabis: To Eat or Not to Eat?	Cannabis	Cannabis effective in treating nausea and vomiting in pregnant women
Show		Cannabis treatments in obstetrics and gynecology: A historical review.	Cannabis	Cannabis was effective in a wide range of gynecological conditions
Show	Tourette's syndrome	Müller-Vahl KR, Schneider U, Emrich HM.	Delta-9-THC	THC may be combined with neuroleptics
Show	Parkinson's disease	Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease: a pilot study.	Nabilone	significant reduction of levodopa-induced dyskinesia
Show	Nausea/vomiting	Antiemetic efficacy of smoked marijuana: subjective and behavioral effects on nausea induced by syrup of ipecac.	Cannabis	Ondansetron superior to cannabis in reducing nausea and vomiting
Show	Spinal cord injury	Clinical investigation of delta-9-tetrahydrocannabinol (THC) as an alternative therapy for overactive bladders in spinal cord injury (SCI) patients.	Delta-9-THC	Significant improvement of some parameters of bladder function
Show	Multiple sclerosis	Acute and chronic effects of cannabis based medicinal extract on refractory lower urinary tract dysfunction in patients with advanced multiple sclerosis – early results	Cannabis	Mean maximum cystometric capacity increased
Show	Pain	[Tetrahydrocannabinol for treatment of chronic pain] [Article in German]	Delta-9-THC	Sufficient pain relief in three patients
Show	Nausea/vomiting; Cancer; Cancer chemotherapy	Effects of smoked cannabis and oral delta-9-tetrahydrocannabinol on nausea and emesis after cancer chemotherapy: A review of state clinical trials.	Cannabis;Delta-9-THC	Cannabis caused symptom relief in 70-100%, dronabinol caused symptom relief in 76-88%
Show	Appetite loss/weight loss;Spasticity;Pain	Marijuana in the management of amyotrophic lateral sclerosis.	Cannabis	Cannabis relieved several symptoms of ALS
Show	HIV/AIDS	Differential Effects of Medical Marijuana Based on Strain and Route of Administration: A Three-Year Observational Study	Cannabis
Show		Hemp for headache: An in-depth historical and scientific review of cannabis in migraine treatment.	Cannabis	Cannabis may be effective in the treatment of headache
Show	Nausea/vomiting; Appetite loss/weight loss;HIV/AIDS	Marijuana Use in HIV-Positive and AIDS Patients: Results of an Anonymous Mail Survey	Cannabis	22.4 % used cannabis for medicinal purposes
Show	Pain	Antinociceptive, subjective and behavioral effects of smoked marijuana in humans.	Cannabis	Cannabis produced dose-dependent antinociception
Show	Multiple sclerosis	Randomised controlled trial of cannabis based medicine (CBM, Stativex®) to treat detrusor overactivity in multiple sclerosis.	Cannabis	There was no effect on daily incontinence, but the cannabis extract was superior to placebo for nocturia.
Show	Tourette's syndrome	Treatment of Tourette's syndrome with delta-9-tetrahydrocannabinol.	Delta-9-THC	Improvement of tics and obsessive-compulsive behavior
Show	Multiple sclerosis; Pain	Analgesic effect of the cannabinoid analogue nabilone is not mediated by opioid receptors.	Nabilone	Relieve of pain
Show	Dependency /withdrawal	Therapeutic use of cannabis by crack addicts in Brazil.	Cannabis	Cannabis use helped patients to quit crack use by reducing the craving symptoms
Show	Dependency/ withdrawal	Therapeutic use of cannabis by crack addicts in Brazil.	Cannabis	Cannabis reduced craving and helped patients to quit cocaine
Show	Bipolar disorders	The use of cannabis as a mood stabilizer in bipolar disorder: anecdotal evidence and the need for clinical research.	Cannabis	A number of patients find cannabis (marihuana) useful in the treatment of their bipolar disorder
Show	Tourette's syndrome	Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome.	Cannabis	Evidence that marijuana improves tics and behavioural disorders in TS.
Show	Parkinson's disease	The effects of the cannabinoid receptor agonist nabilone on L-DOPA induced dyskinesia in patients with idiopathic Parkinson's disease (PD).	Nabilone	Activation of cannabinoid receptors can reduce L-DOPA-induced dyskinesia in man without aggravating parkinsonism.
Show	Hiccups	Marijuana for intractable hiccups.	Cannabis	Smoking cannabis stopped hiccups that did not respond to usual medications on the 8th day
Show	Spasticity;Multiple sclerosis;Pain; Tremor;Depression	The perceived effects of smoked cannabis on patients with multiple sclerosis.	Cannabis	In more than 80% improvement of spasticity, pain, tremor, depression, anxiety, and paresthesia
Show	Pain	Pain relief with oral cannabinoids in familial Mediterranean fever.	Cannabis	reduction of need for morphin
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Intractable nausea and vomiting due to gastrointestinal mucosal metastases relieved by tetrahydrocannabinol (dronabinol).	Delta-9-THC	patients was treated with several antiemetic drugs, but it was not until dronabinol was added that the nausea and vomiting stopped
Show	Appetite loss/weight loss;HIV/AIDS	Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia.	Delta-9-THC	tendency to stable weight for 7 months
Show	Appetite loss/weight loss;HIV/AIDS	The safety and pharmacokinetics of single-agent and combination therapy with megestrol acetate and dronabinol for the treatment of HIV wasting syndrome. The DATRI 004 Study Group. Division of AIDS Treatment Research Initiative.	Delta-9-THC	weight loss with THC, weight gain with megestrol acetate
Show	Appetite loss/ weight loss; Alzheimer's disease	Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.	Delta-9-THC	higher weight gain with THC; reduction of disturbed behaviour with THC
Show	Nausea/vomiting; Cancer chemotherapy	Marijuana to prevent nausea and vomiting in cancer patients: a survey of clinical oncologists.	Cannabis	Only a small percentage of oncologists prescribed marijuana
Show	Multiple sclerosis; Spinal cord injury; Spasticity; Pain	The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity: a pilot study with 2 patients.	Delta-9-THC	improvement of joint function and ability to walk; in 1 patient additional alleviation of pain
Show	Cancer chemotherapy; Nausea/vomiting	An efficient new cannabinoid antiemetic in pediatric oncology.	Delta-9-THC	complete prevention of emesis
Show	Multiple sclerosis; Spasticity	Nabilone in the treatment of multiple sclerosis.	Nabilone	improvement of muscle spasms and frequency of nocturia
Show	Appetite loss/weight loss;HIV/AIDS; Depression	Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS.	Delta-9-THC	increased appetite; improvement in mood; stabel weight
Show	Spasticity; Spinal cord injury	Treatment of spasticity in spinal cord injury with dronabinol, a tetrahydrocannabinol derivative.	Delta-9-THC	Spasticity was markedly improved in 2 o 5 patients
Show	Appetite loss/ weight loss;Cancer	A phase II study of delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia.	Delta-9-THC	increase of appetite in 13 patients
Show	Multiple sclerosis	Short-term effects of smoking marijuana on balance in patients with multiple sclerosis and normal volunteers	Cannabis	Cannabis reduced posture and balance in patients with MS
Show	Nausea/vomiting	Effect of nabilone on nausea and vomiting after total abdominal hysterectomy.	Nabilone	Nabilone and metoclopramide were equally effective in reducing nausea and vomiting
Show	Appetite loss/weight loss;HIV/AIDS	Effect of dronabinol on nutritional status in HIV infection.	Delta-9-THC	Trends toward weight gain, improved appetite, decreased symptom stress
Show	Tourette's syndrome	Effective treatment of Tourette’s syndrome with marijuana.	Cannabis	Improvement of symptoms with cannabis
Show	HIV/AIDS; Appetite loss/ weight loss; Depression	Dronabinol stimulates appetite and causes weight gain in HIV patients.	Delta-9-THC	increase in appetite, trend toward weight gain
Show	Appetite loss/weight loss;HIV/AIDS	Dronabinol effects on weight in patients with HIV infection.	Delta-9-THC	weight gain
Show	Nausea/vomiting; Cancer; Cancer chemotherapy	Dronabinol and prochlorperazine in combination for treatment of cancer chemotherapy-induced nausea and vomiting.	Delta-9-THC	prochlorperazine better than THC, both drugs combined better than both alone
Show	Appetite loss/weight loss;HIV/AIDS	Recent clinical experience with dronabinol.	Delta-9-THC	Significant weight gain
Show		Controlled clincal trial of cannabidiol in Huntington's disease.	Cannabidiol	CBD was neither symptomatically effective nor toxic.
Show	Nausea/vomiting ;Cancer chemotherapy	Marijuana as antiemetic medicine: a survey of oncologists' experiences and attitudes.	Cannabis	54% of oncologists thought marijuana should be available on prescription
Show	Spasticity;Spinal cord injury;Pain	Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects in a single case double-blind trial.	Delta-9-THC	THC and codeine reduced pain; THC reduced spasticity
Show	Appetite loss/ weight loss;Cancer	Dronabinol enhancement of appetite in cancer patients.	Delta-9-THC	Patients continued to loose, but the weight loss decreased in all groups; appetite and mood increased
Show	Parkinson's disease	Marijuana for parkinsonian tremor.	Cannabis	No improvement of tremor
Show	Appetite loss/ weight loss;Cancer	Dronabinol enhancement of appetite in cancer patients.	Delta-9-THC	Dronabinol stimulated mood and appetite
Show	Multiple sclerosis; Spasticity; Ataxia	Effect of cannabinoids on spasticity and ataxia in multiple sclerosis.	Cannabis	improvement of tremor, spasticity and ataxia
Show	Nausea/vomiting ;HIV/AIDS	Nabilone as effective therapy for intractable nausea and vomiting in AIDS.	Nabilone	Intractable nausea and vomiting was effectively relieved with nabilone
Show	Nausea/vomiting; Cancer; Cancer chemotherapy	Efficacy of tetrahydrocannabinol in patients refractory to standard anti-emetic therapy	Delta-9-THC	THC decreased nausea and vomiting in 23 of 36 (64%) patients
Show	Appetite loss/weight loss	Effects of smoked marijuana on food intake and body weight of humans living in a residential laboratory.	Cannabis	Increases in body weight during periods of active marijuana smoking were greater than predicted by caloric intake alone.
Show	Nausea/vomiting; Cancer ;Cancer chemotherapy	A randomized trial of oral nabilone and prochlorperazine compared to intravenous metoclopramide and dexamethasone in the treatment of nausea and vomiting induced by chemotherapy regimens containing cisplatin or cisplatin analogues.	Nabilone	Metoclopramide/dexamethasone superior to nabilone/prochlorperazine
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Inhalation marijuana as an antiemetic for cancer chemotherapy.	Cannabis	Marijuana effective as antiemetic agent
Show	Tourette's syndrome	Marijuana and Tourette’s syndrome.	Cannabis	The patients notes a significant amelioration of symptoms when smoking cannabis
Show	Multiple sclerosis; Spasticity	Delta-9-THC in the treatment of spasticity associated with multiple sclerosis.	Delta-9-THC	significant subjective improvement in spasticity at doses of 7.5 mg and above; no objective improvement
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children: a double-blind, crossover trial.	Nabilone	Nabilone effective as antiemetic drug for children
Show	Nausea/vomiting	A double-blind randomised cross-over comparison of nabilone and metoclopramide in the control of radiation-induced nausea.	Nabilone	Nabilone similar effective as metoclopramide
Show	Pain	Lack of effect of cannabidiol in sustained neuropathia.	Cannabidiol	no effect of CBD on pain
Show	Dystonia; Parkinson's disease	Open label evaluation of cannabidiol in dystonic movement disorders.	Cannabidiol	20-50% improvement of dystonia; deterioration of tremor and hypokinesia in 2 patients with Parkinson's disease
Show	Epilepsy	Anticonvulsant effect of cannabidiol.	Cannabidiol	no significant effect in addition to standard medication
Show	Spasticity	Effect of Delta-9-THC on EMG Measurements in Human Spasticity	Delta-9-THC	THC reduced several types of spastic manifestations
Show	Appetite loss/ weight loss	Behavioral analysis of marijuana effects on food intake in humans.	Cannabis	The administration of two or three active marijuana cigarettes during the social access period increased average daily caloric intake.
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Nabilone and metoclopramide in the treatment of nausea and vomiting due to cisplatinum: a double blind study.	Nabilone	No difference between nabilone and metoclopramide
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Nabilone: an alternative antiemetic for cancer chemotherapy.	Nabilone	Even for young children nabilone is an effective antiemetic, superior to domperidone.
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Crossover comparison of the antiemetic efficacy of nabilone and alizapride in patients with nonseminomatous testicular cancer receiving cisplatin therapy.	Nabilone	Nabilone superior to alizapride.
Show	Nausea/vomiting ;Cancer;Cancer chemotherapy	Prospective randomized double-blind trial of nabilone versus domperidone in the treatment of cytotoxic-induced emesis.	Nabilone	Nabilone superior to domperidone
Show	Dystonia	Cannabidiol in dystonic movement disorders.	Cannabidiol	Cannabidiol (CBD) reduced dystonic movements
Show	Spasticity	The effect of delta-9-THC on human spasticity.	Delta-9-THC	Delta-9-THC proved clinically beneficial in two of five patients with intractable spasticity.
Show	Nausea/vomiting;Cancer ;Cancer chemotherapy	THC or Compazine for the cancer chemotherapy patient–the UCLA study. Part II: Patient drug preference.	Delta-9-THC	nausea reduction was the main determinant of preference between THC and prochlorperazine
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	A cross-over comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy.	Nabilone	Nabilone is a moderately effective anti-emetic drug
Show	Parkinson's disease	Beneficial and adverse effects of cannabidiol in a Parkinson patient with sinemet-induced dystonic dyskinesia.	Cannabidiol	Improvement of dyskinesia
Show	Cancer;Cancer chemotherapy	Antiemetic efficacy of levonantradol compared to delta-9-tetrahydrocannabinol for chemotherapy-induced nausea and vomiting.	Delta-9-THC;Other cannabinoids	Levonantradol appears to be at least as effective an antiemetic as THC ; well-tolerated side-effects.
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Antiemetic therapy: a review of recent studies and a report of a random assignment trial comparing metoclopramide with delta-9-tetrahydrocannabinol.	Delta-9-THC	Poorer antiemetic control and more side effects with dronabinol than with the metoclopramide, both better than placebo
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Randomized double blind comparison of delta-9-tetrahydroicannabinol (THC) and marijuana as chemotherapy antiemetics.	Cannabis;Delta-9-THC	9 patients no preference; 7 preferred oral THC, 4 preferred marijuana cigarettes (double-blind, double dummy crossover study)
Show	Asthma	Acute and subacute bronchial effects of oral cannabinoids.	Delta-9-THC	acute bronchodilator activity of delta 9-THC; no effect of cannabidiol; daily use of delta 9-THC not associated with tolerance
Show	Dystonia	Treatment of Meige's syndrome with cannabidiol.	Cannabidiol	50% improvement in spasm severity and frequency
Show	Cancer chemotherapy	Dose ranging evaluation of the antiemetic efficacy and toxicity of intramuscular levonantradol in cancer subjects with chemotherapy-induced emesis.	Other cannabinoids	Levonantradol more effective than placebo
Show	Nausea/vomiting; Cancer	An initial evaluation of Nabilone in the control of radiotherapy-induced nausea and vomiting.	Nabilone	Patients who did not respond to metaclopramide responded to nabilone.
Show	Nausea/vomiting ;Cancer	Tetrahydrocannabinol vs. prochlorperazine. The effects of two antiemetics on patients undergoing radiotherapy.	Delta-9-THC	THC was slightly superior to prochlorperazine
Show	Multiple sclerosis; Tremor	Tetrahydrocannabinol for tremor in multiple sclerosis.	Delta-9-THC	2 patients with objective improvement, 5 with subjective improvement
Show	Asthma	Comparison of bronchial effects of nabilone and terbutaline in healthy and asthmatic subjects.	Nabilone	moderate bronchodilator action in healthy subjects; no difference to placebo in asthmatics
Show	Appetite loss/ weight loss	A double-blind trial of delta 9-tetrahydrocannabinol in primary anorexia nervosa.	Delta-9-THC	no significant difference between THC and diazepam
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Anti-emetic efficacy and toxicity of nabilone, a synthetic cannabinoid, in lung cancer chemotherapy.	Nabilone	Symptom scores were significantly better for patients on nabilone for nausea, retching and vomiting.
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	[Randomized comparative trial of a new anti-emetic: nabilone, in cancer patients treated with cisplatin][Article in French]	Nabilone	Nabilone, in comparison with chlorpromazine did not significantly reduce the number of vomiting, but most patients preferred nabilone.
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	A randomised multicentre single blind comparison of a cannabinoid anti-emetic (levonantradol) with chlorpromazine in patients receiving their first cytotoxic chemotherapy.	Other cannabinoids	0.5 mg levonantradol was a more effective antiemtic than 25 mg chlorpromazine
Show	Nausea/vomiting ;Cancer chemotherapy	Cannabis and cancer chemotherapy: a comparison of oral delta-9-THC and prochlorperazine.	Delta-9-THC	No significant differences between THC and prochlorperazine
Show	Spasticity;Spinal cord injury	Cannabis effect on spasticity in spinal cord injury.	Cannabis	Decreased spasticity with marijuana use
Show	Nausea/vomiting	Randomised clinical trial of levonantradol and chlorpromazine in the prevention of radiotherapy-induced vomiting.	Other cannabinoids	The frequency of vomiting was similar after levonantradol and chlorpromazine.
Show	Cancer;Cancer chemotherapy	A double-blind, controlled trial of nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy.	Nabilone	Severity of nausea and number of vomiting ejections and dry retching episodes were significantly less under nabilone.
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	A multi-institutional Phase III study of nabilone vs. placebo in chemotherapy-induced nausea and vomiting.	Nabilone	Nabilone is an effective antiemetic agent for chemotherapy-induced nausea and vomiting.
Show	Spasticity	Treatment of human spasticity with delta 9-tetrahydrocannabinol.	Delta-9-THC	reduced spasticity with 10 mg THC
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	A prospective evaluation of delta-9-tetrahydrocannabinol as an antiemetic in patients receiving adriamycin and cytoxan chemotherapy.	Delta-9-THC	no significant reduction of the number of vomiting, volume of emesis, degree of nausea, or duration of nausea
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Dose vs response of tetrahydroannabinol (THC) vs prochlorperazine as chemotherapy antiemetics.	Delta-9-THC	THC 15 mg was the most effective against vomiting, prochlorperazine was the most effective antinauseant
Show	Pain	Evaluation of intramuscular levonantradol and placebo in acute postoperative pain.	Other cannabinoids	significant pain relief compared with placebo
Show	Glaucoma	Topical delta 9-tetrahydrocannabinol and aqueous dynamics in glaucoma.	Delta-9-THC	no effect
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Comparative trial of the antiemetic effects of THC and haloperidol	Delta-9-THC	THC and haloperidol equally effective
Show	Cancer chemotherapy; Glaucoma	Physiologic observations in a controlled clinical trial of the antiemetic effectiveness of 5, 10, and 15 mg of delta 9-tetrahydrocannabinol in cancer chemotherapy. Ophthalmologic implications.	Delta-9-THC	Patients were remarkably free of adverse physiologic effects.
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Nabilone: an effective antiemetic in patients receiving cancer chemotherapy.	Nabilone	Sixty patients (75 per cent) reported nabilone to be more effective than prochlorperazine for relief of nausea and vomiting.
Show	Pain	A study of levonantradol, a cannabinol derivative, for analgesia in post operative pain.	Other cannabinoids	Levonantradol has analgetic activity but may have central nervous system adverse effects in humans.
Show	Glaucoma	Clinical relevance of cannabis tolerance and dependence.	Delta-9-THC
Show	Anxiety	The efficacy and safety of nabilone (a synthetic cannabinoid) in the treatment of anxiety.	Nabilone	Dramatic improvement in anxiety
Show	Anxiety	Single-dose study of nabilone in anxious volunteers.	Nabilone	Antianxiety effects in 2 of the 8 subjects
Show	Pain	Effects of moderate and high doses of marihuana on thermal pain: a sensory decision theory analysis.	Cannabis	Cannabis increased perseption of pain
Show	Cancer chemotherapy; Nausea/vomiting	Antiemetics in patients receiving chemotherapy for cancer: a randomized comparison of delta-9-tetrahydrocannabinol and prochlorperazine.	Delta-9-THC	no nausea and vomiting in 36 of 79 courses of chemotherapy with THC compared to 16 of 78 courses in patients who received prochlorperazine; improved appetite with THC
Show	Cancer chemotherapy; Nausea/vomiting	Antiemetic effect of tetrahydrocannabinol. Compared with placebo and prochlorperazine in chemotherapy-associated nausea and emesis.	Delta-9-THC	no nausea and no vomiting (complete response) in 73% (40/55 courses) in THC group
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	The antiemetic activity of tetrahydrocanabinol versus metoclopramide and thiethylperazine in patients undergoing cancer chemotherapy.	Delta-9-THC	tetrahydrocannabinol given by mouth has an antiemetic effect of approximately the same order as thiethylperazine and metoclopramide
Show	Epilepsy	Chronic administration of cannabidiol to healthy volunteers and epileptic patients.	Cannabidiol	4 of the 8 CBD subjects remained almost free of convulsive crises and 3 other patients demonstrated partial improvement
Show	Spasticity;Pain	Marihuana as a therapeutic agent for muscle spasm or spasticity.	Cannabis	Relief from spasticity and pain
Show	Glaucoma	Effect of marihuana on intraocular and blood pressure in glaucoma.	Cannabis	Marihuana inhalation decreased intraocular and blood pressure.
Show	Cancer;Cancer chemotherapy	Double-blind comparison of the antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis.	Nabilone	Both nabilone and prochlorperazine produced antiemetic effects
Show	Epilepsy	Chronic administration of cannabidiol to healthy volunteers and epileptic patients.	Cannabidiol	4 of the 8 CBD subjects remained almost free of convulsive crises and 3 other patients demonstrated partial improvement
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy. A comparison with prochlorperazine and a placebo.	Delta-9-THC	THC and PCP equally effective; both better than placebo; THC produced psychic effects in 82%
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Delta-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate. A prospective, randomized evaluation.	Delta-9-THC	14 of 15 patients had decreased vomiting and nausea
Show	Nausea/vomiting; Cancer;Cancer chemotherapy	Delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy; a double-blind cross-over trial against placebo	Delta-9-THC	dronabinol superior to placebo (P<.01 for difference between groups at days 1 and 8 independently)
Show	Glaucoma	Effects of tetrahydrocannabinol on arterial and intraocular hypertension.	Cannabis	drop in IOP parallel with drop in arterial blood pressure
Show	Nausea/vomiting	Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-tetrahydrocannabinol.	Delta-9-THC	THC was effective in reducing nausea and vomiting but not in all patients
Show	Nausea/vomiting ;Cancer;Cancer chemotherapy	Superiority of nabilone over prochlorperazine as an antiemetic in patients receiving cancer chemotherapy.	Nabilone	When both drugs were compared, both nausea and vomiting episodes were significantly lower in patients given nabilone.
Show	Pain	Effect of benzopyranoperidine, a delta-9-THC congener, on pain.	Other cannabinoids	Bezopyranoperidine was not more effective than placebo
Show	Cancer;Pain	Effect of a nitrogen analog of tetrahydrocannabinol on cancer pain.	Other cannabinoids	NIB was superior to placebo and to secobarbital but is not useful clinically because of the frequency of side effects.
Show	Glaucoma	Effect of delta-9-tetrahydrocannabinol on intraocular pressure in humans.	Delta-9-THC	reduction in intraocular pressure
Show	Pain	Effects of intravenous tetrahydrocannabinol on experimental and surgical pain. Psychological correlates of the analgesic response.	Delta-9-THC	No pain relief with THC
Show	Asthma	Bronchial effects of aerosolized delta 9-tetrahydrocannabinol in healthy and asthmatic subjects.	Delta-9-THC	THC effective in healthy subjects and 3 asthmatic subjects; aerosol caused bronchoconstriction in 2 asthmatic subjects
Show	Cancer; Appetite loss/weight loss; Depression		Delta-9-THC	weight gain with THC; weight los with placebo
Show	Asthma	Bronchodilator effect of delta1-tetrahydrocannabinol administered by aerosol of asthmatic patients.	Delta-9-THC	significant broncholdilation with THC; faster action of salbutamol but both drugs equivalent at 1 hour
Show	Cancer chemotherapy; Nausea/vomiting	Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy.	Delta-9-THC	for patients completing the study there were 5 complete responses (no vomiting) and 7 partial responses (50% decrease of vomiting) of overall 15 courses
Show	Cancer; Pain	Analgesic effect of delta-9-tetrahydrocannabinol.	Delta-9-THC	pain relief with 15-20 mg THC
Show	Cancer; Pain	The analgesic properties of delta-9-tetrahydrocannabinol and codeine.	Delta-9-THC	milde analgesic effect; with 20 mg THC strong adverse effects
Show	Epilepsy	Anticonvulsant nature of marihuana smoking.	Cannabis	Cannabis was able to control seizures in conjunction with phenobarbital and diphenylhydantoin.
Show	Asthma	Effects of smoked marijuana in experimentally induced asthma.	Cannabis	after experimental induction of acute bronchospasm prompt correction of the bronchospasm with cannabis
Show	Glaucoma	Marijuana smoking and reduced pressure in human eyes: drug action or epiphenomenon?	Delta-9-THC	IOP reduction in 7 of 15
Show	Asthma	Acute effects of smoked marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance in asthmatic subjects.	Cannabis;Delta-9-THC;Cannabidiol	Smoked marijuana and oral THC caused significant bronchodilation of at least 2 hours duration.
Show	Spasticity;Spinal cord injury;Pain	The perceived effects of marijuana on spinal cord injured males.	Cannabis	Decrease in pain and spasticity.
Show	Pain	Marihuana and pain.	Cannabis	Cannabis increased pain sensitivity
Show	Glaucoma	Marihuana smoking and intraocular pressure.	Cannabis	9 of 11 had drop in intraocular pressure of 16-45%
Show	Dependency/ withdrawal	Cannabis substitution. An adjunctive therapeutic tool in the treatment of alcoholism.	Cannabis	Marijuana consumption may help to decrease alcolholic intake.
Show	Pain	Tetrahydrocannabinol Does not Reduce Pain in Patients With Chronic Abdominal Pain in a Phase 2 Placebo-controlled Study.	Delta-9-THC	No effect of THC on pain in patients with abdominal pain
Show	Pain	The Effect of Medicinal Cannabis on Pain and Quality of Life Outcomes in Chronic Pain: A Prospective Open-label Study.	Cannabis	Cannabis reduced pain and opioid use

מגזין רפואי חרט על דגלו להביא את המחקרים והמאמרים האמינים ביותר אך אינו מהווה עצה רפואית או חוות דעת מקצועית ואינו תחליף להתייעצות עם איש מקצוע מוסמך, בכל בעיה רפואית או נפשית יש להיוועץ ברופא המלווה שלכם.